IMPROVED SYNTHESIS OF SUBSTITUTED 2-ARYL-N- [2-(DIMETHYLAMINO)ETHYL]QUINOLIN-4-AMINES AND THEIR ACTIVITY AS ANTAGONISTS OF IMMUNOSTIMULATORY CpG-OLIGODEOXYNUCLEOTIDES

Ekaterina Paliakov; Maged Henary; Martial Say; Lubomir Janda; Lori Manzel; Donald E Macfarlane; Lucjan Strekowski

doi:10.1515/HC.2007.13.1.9

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IMPROVED SYNTHESIS OF SUBSTITUTED 2-ARYL-N- [2-(DIMETHYLAMINO)ETHYL]QUINOLIN-4-AMINES AND THEIR ACTIVITY AS ANTAGONISTS OF IMMUNOSTIMULATORY CpG-OLIGODEOXYNUCLEOTIDES

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IMPROVED SYNTHESIS OF SUBSTITUTED 2-ARYL-N- [2-(DIMETHYLAMINO)ETHYL]QUINOLIN-4-AMINES AND THEIR ACTIVITY AS ANTAGONISTS OF IMMUNOSTIMULATORY CpG-OLIGODEOXYNUCLEOTIDES

Ekaterina Paliakov, Maged Henary, Martial Say, Lubomir Janda, Lori Manzel, Donald E Macfarlane and Lucjan Strekowski

Heterocyclic communications, Vol.13(1), pp.9-12

01/2007

DOI: 10.1515/HC.2007.13.1.9

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Abstract

A general methodology for the synthesis of substituted quinolin-4-amines developed by us previously has been simplified. The synthesized compounds, depending on substituents, show activities in the range from 35 nM to 550 nM as antagonists of immunostimulatory oligodeoxynucleotides containing a CpG motif. A SAR analysis is presented.

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Title: Subtitle: IMPROVED SYNTHESIS OF SUBSTITUTED 2-ARYL-N- [2-(DIMETHYLAMINO)ETHYL]QUINOLIN-4-AMINES AND THEIR ACTIVITY AS ANTAGONISTS OF IMMUNOSTIMULATORY CpG-OLIGODEOXYNUCLEOTIDES
Creators: Ekaterina Paliakov
Maged Henary
Martial Say
Lubomir Janda
Lori Manzel
Donald E Macfarlane
Lucjan Strekowski
Resource Type: Journal article
Publication Details: Heterocyclic communications, Vol.13(1), pp.9-12
DOI: 10.1515/HC.2007.13.1.9
ISSN: 0793-0283
eISSN: 2191-0197
Language: English
Date published: 01/2007
Academic Unit: Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
Record Identifier: 9984359937902771

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