Journal article
INHIBITION OF TUMOR-CELL GROWTH INVITRO AND INVIVO BY 1-BETA-D-ARABINOFURANOSYLCYTOSINE ENTRAPPED WITHIN PHOSPHOLIPID VESICLES
Cancer research (Chicago, Ill.), Vol.36(12), pp.4406-4411
01/01/1976
PMID: 187321
Abstract
Phospholipid vesicles have been used as a carrier vehicle to enhance the cytotoxic activity of 1-beta-D-arabinofuranosyl-cytosine (ara-C) and 1-beta-D-arabinofuranosylcytosine 5'-triphosphate against several tumor cell lines. The activity of both compounds in free solution or entrapped within phospholipid vesicles was compared against L1210 cells, Ehrlich ascites cells, and SV40-transformed 3T3 cells in vitro. In addition, the activity of vesicle-entrapped ara-C against L1210 cells was also studied in vivo. The results obtained in vitro with ara-C indicated no difference in the concentration needed to inhibit growth of cells by 50% between free ara-C and vesicle-entrapped ara-C. In contrast, 1-beta-D-arabinofuranosylcytosine 5'-triphosphate entrapped in phospholipid vesicles was a more potent inhibitor of L1210 in culture (ID50, 2 X 10(-8) M) compared to the relatively inactive free 1-beta-D-arabinofuranosylcytosine 5'-triphosphate (id50 greater than 10(-7) M). Experiments carried out with L1210 cells in mice showed that, after a single i.p. dose (10 mg/kg) of vesicle-entrapped ara-C, the average survival times of mice inoculated with 10(5) L1210 cells were increased by over 90%. In control experiments, free ara-C or vesicles plus free ara-C (10 mg/kg) did not prolong survival of mice.
Details
- Title: Subtitle
- INHIBITION OF TUMOR-CELL GROWTH INVITRO AND INVIVO BY 1-BETA-D-ARABINOFURANOSYLCYTOSINE ENTRAPPED WITHIN PHOSPHOLIPID VESICLES
- Creators
- E MayhewD PapahadjopoulosY M RustumC Dave
- Resource Type
- Journal article
- Publication Details
- Cancer research (Chicago, Ill.), Vol.36(12), pp.4406-4411
- Publisher
- Amer Assoc Cancer Research
- PMID
- 187321
- ISSN
- 0008-5472
- eISSN
- 1538-7445
- Number of pages
- 6
- Language
- English
- Date published
- 01/01/1976
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984359586002771
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