INSIGHTS INTO THE ORIGINS OF CYSTIC FIBROSIS LUNG DISEASE

DAVID A. Stoltz

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INSIGHTS INTO THE ORIGINS OF CYSTIC FIBROSIS LUNG DISEASE

Journal article

Open access

INSIGHTS INTO THE ORIGINS OF CYSTIC FIBROSIS LUNG DISEASE

DAVID A. Stoltz

Transactions of the American Clinical and Climatological Association, Vol.134, pp.29-36

01/01/2024

PMCID: PMC11316882

PMID: 39135587

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11316882/View

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Abstract

In this paper, I will discuss recent studies using a cystic fibrosis pig model to better understand the origins of cystic fibrosis lung disease. Specifically, I will review our work investigating how loss of the cystic fibrosis transmembrane conductance regulator function (CFTR) impairs mucociliary transport in the cystic fibrosis airway. These studies reveal new insights into the early, underlying mechanisms of cystic fibrosis lung disease and could lead to novel therapeutic interventions.

Details

Title: Subtitle: INSIGHTS INTO THE ORIGINS OF CYSTIC FIBROSIS LUNG DISEASE
Creators: DAVID A. Stoltz - Iowa City, Iowa
Resource Type: Journal article
Publication Details: Transactions of the American Clinical and Climatological Association, Vol.134, pp.29-36
Publisher: American Clinical and Climatological Association
PMID: 39135587
PMCID: PMC11316882
ISSN: 0065-7778
Language: English
Date published: 01/01/2024
Academic Unit: Molecular Physiology and Biophysics; Pulmonary, Critical Care, and Occupational Medicine; Internal Medicine
Record Identifier: 9984697060302771

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