INSPPIRE: Advances in the Understanding of Pediatric Pancreatitis

Aliye Uc; Maisam Abu-El-Haija; Melena D Bellin; Gretchen Cress; Elissa M Downs; Tanja Y Gonska; Sohail Z Husain; Robert A Noel; Mark E Lowe; Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC)

doi:10.1097/MPA.0000000000002673

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INSPPIRE: Advances in the Understanding of Pediatric Pancreatitis

Journal article

Peer reviewed

INSPPIRE: Advances in the Understanding of Pediatric Pancreatitis

Aliye Uc, Maisam Abu-El-Haija, Melena D Bellin, Gretchen Cress, Elissa M Downs, Tanja Y Gonska, Sohail Z Husain, Robert A Noel, Mark E Lowe and Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC)

Pancreas

05/27/2026

DOI: 10.1097/MPA.0000000000002673

PMID: 42200466

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Abstract

This is the summary of an April 2025 Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer (CPDPC) workshop highlighting the accomplishments of INSPPIRE (INternational Study Group of Pediatric Pancreatitis: In search for a cuRE)-2. INSPPIRE-2 goals and objectives have been to study the risk factors, natural history and outcomes of pediatric acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP). Structured patient and physician questionnaires have been used to collect information on demographics, clinical history, family and social history, and disease outcomes. Biosamples have been collected primarily for DNA isolation and analysis of key genes associated with pancreatitis, alongside ancillary studies aimed at elucidating disease pathophysiology and advancing the development of improved diagnostic and therapeutic strategies. Twenty-six sites have enrolled >1000 subjects into the INSPPIRE-2 database with available prospective data to evaluate disease progression, phenotypes, complications and outcomes. The available resources are outlined along with key discoveries offering readers topic specific information about INSPPIRE's progress.

Diabetes

Pancreas

pancreatitis

child

Details

Title: Subtitle: INSPPIRE: Advances in the Understanding of Pediatric Pancreatitis
Creators: Aliye Uc - University of Iowa
Maisam Abu-El-Haija - Cincinnati Children's Hospital Medical Center
Melena D Bellin - University of Minnesota Children's Hospital
Gretchen Cress - University of Iowa
Elissa M Downs - University of Minnesota Children's Hospital
Tanja Y Gonska - Hospital for Sick Children
Sohail Z Husain - Stanford Health Care
Robert A Noel - Baylor College of Medicine
Mark E Lowe - Washington University in St. Louis
Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC)
Resource Type: Journal article
Publication Details: Pancreas
DOI: 10.1097/MPA.0000000000002673
PMID: 42200466
NLM abbreviation: Pancreas
ISSN: 1536-4828
eISSN: 1536-4828
Language: English
Electronic publication date: 05/27/2026
Academic Unit: Stead Family Department of Pediatrics; Gastroenterology, Hepatology, Pancreatology, and Nutrition
Record Identifier: 9985166961902771

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