Journal article
INternational Study Group of Pediatric Pancreatitis: In Search for a CuRE Cohort Study: Design and Rationale for INSPPIRE 2 From the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer
Pancreas, Vol.47(10), pp.1222-1228
11/2018
DOI: 10.1097/MPA.0000000000001172
PMCID: PMC6195325
PMID: 30325861
Abstract
We created the INternational Study Group of Pediatric Pancreatitis: In Search for a CuRE (INSPPIRE 2) cohort to study the risk factors, natural history, and outcomes of pediatric acute recurrent pancreatitis and chronic pancreatitis (CP). Patient and physician questionnaires collect information on demographics, clinical history, family and social history, and disease outcomes. Health-related quality of life, depression, and anxiety are measured using validated questionnaires. Information entered on paper questionnaires is transferred into a database managed by Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer's Coordinating and Data Management Center. Biosamples are collected for DNA isolation and analysis of most common pancreatitis-associated genes.Twenty-two sites (18 in the United States, 2 in Canada, and 1 each in Israel and Australia) are participating in the INSPPIRE 2 study. These sites have enrolled 211 subjects into the INSPPIRE 2 database toward our goal to recruit more than 800 patients in 2 years. The INSPPIRE 2 cohort study is an extension of the INSPPIRE cohort study with a larger and more diverse patient population. Our goals have expanded to include evaluating risk factors for CP, its sequelae, and psychosocial factors associated with pediatric acute recurrent pancreatitis and CP.
Details
- Title: Subtitle
- INternational Study Group of Pediatric Pancreatitis: In Search for a CuRE Cohort Study: Design and Rationale for INSPPIRE 2 From the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer
- Creators
- Aliye UcEmily R Perito - Department of Pediatrics, University of California San Francisco, San Francisco, CAJohn F Pohl - Department of Pediatrics, University of Utah, Salt Lake City, UTUzma Shah - Department of Pediatrics, Massachusetts General Hospital for Children, Harvard Medical School, Boston, MAMaisam Abu-El-Haija - Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OHBradley Barth - Department of Pediatrics, University of Texas Southwestern Medical School, Dallas, TXMelena D Bellin - Department of Pediatrics, University of Minnesota Masonic Children's Hospital, Minneapolis, MNKate M Ellery - Department of Pediatrics, Children's Hospital of Pittsburgh, Pittsburgh, PADouglas S Fishman - Department of Pediatrics, Baylor College of Medicine, Houston, TXCheryl E Gariepy - Department of Pediatrics, Nationwide Children's Hospital, Columbus, OHMatthew J Giefer - Department of Pediatrics, Seattle Children's Hospital, Seattle, WATanja Gonska - Department of Pediatrics, Hospital for Sick Children, Toronto, CanadaMelvin B Heyman - Department of Pediatrics, University of California San Francisco, San Francisco, CARyan W Himes - Department of Pediatrics, Baylor College of Medicine, Houston, TXSohail Z Husain - Department of Pediatrics, Children's Hospital of Pittsburgh, Pittsburgh, PAAsim Maqbool - Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PAMaria R Mascarenhas - Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PABrian A McFerron - Department of Pediatrics, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, INVeronique D Morinville - Department of Pediatrics, Montreal Children's Hospital, McGill University, Montreal, CanadaTom K Lin - Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OHQuin Y Liu - Department of Pediatrics and Medicine, Cedars-Sinai Medical Center, Los Angeles, CAJaimie D Nathan - Division of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OHSue J Rhee - Department of Pediatrics, University of California San Francisco, San Francisco, CAChee Y Ooi - Department of Pediatrics, School of Women's and Children's Health, Medicine, University of New South Wales and Sydney Children's Hospital, Sydney, AustraliaZachary M Sellers - Department of Pediatrics, Stanford University, Stanford, CASarah Jane Schwarzenberg - Department of Pediatrics, University of Minnesota Masonic Children's Hospital, Minneapolis, MNJose Serrano - Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Bethesda, MDDavid M Troendle - Department of Pediatrics, University of Texas Southwestern Medical School, Dallas, TXSteven L Werlin - Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WIMichael Wilschanski - Department of Pediatrics, Hadassah Hebrew University Hospital, Jerusalem, IsraelYuhua Zheng - Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CAYing Yuan - Department of Biostatistics, The University of Texas, MD Anderson Cancer Center, Houston, TXMark E Lowe - Department of Pediatrics, Washington University School of Medicine, St Louis, MO
- Resource Type
- Journal article
- Publication Details
- Pancreas, Vol.47(10), pp.1222-1228
- DOI
- 10.1097/MPA.0000000000001172
- PMID
- 30325861
- PMCID
- PMC6195325
- NLM abbreviation
- Pancreas
- ISSN
- 0885-3177
- eISSN
- 1536-4828
- Publisher
- United States
- Grant note
- R01 DK097820 / NIDDK NIH HHS UL1 TR002538 / NCATS NIH HHS U01 DK108326 / NIDDK NIH HHS R21 DK096327 / NIDDK NIH HHS U01 DK108334 / NIDDK NIH HHS
- Language
- English
- Date published
- 11/2018
- Academic Unit
- Stead Family Department of Pediatrics; Radiation Oncology; Gastroenterology, Hepatology, Pancreatology, and Nutrition
- Record Identifier
- 9984046924202771
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