Identification and function of thermosensory neurons in Drosophila larvae

Lei Liu; Olena Yermolaieva; Wayne A Johnson; Francois M Abboud; Michael J Welsh

doi:10.1038/nn1009

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Identification and function of thermosensory neurons in Drosophila larvae

Journal article

Peer reviewed

Identification and function of thermosensory neurons in Drosophila larvae

Lei Liu, Olena Yermolaieva, Wayne A Johnson, Francois M Abboud and Michael J Welsh

Nature neuroscience, Vol.6(3), pp.267-273

03/2003

DOI: 10.1038/nn1009

PMID: 12563263

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Abstract

Although the ability to sense temperature is critical for many organisms, the underlying mechanisms are poorly understood. Using the calcium reporter yellow cameleon 2.1 and electrophysiological recordings, we identified thermosensitive neurons and examined their physiologic response in Drosophila melanogaster larvae. In the head, terminal sensory organ neurons showed increased activity in response to cooling by < or =1 degrees C, heating reduced their basal activity, and different units showed distinct response patterns. Neither cooling nor heating affected dorsal organ neurons. Body wall neurons showed a variety of distinct response patterns to both heating and cooling; the diverse thermal responses were strikingly similar to those described in mammals. These data establish a functional map of thermoresponsive neurons in Drosophila larvae and provide a foundation for understanding mechanisms of thermoreception in both insects and mammals.

Neurons, Afferent - cytology

Promoter Regions, Genetic

Temperature

Animals, Genetically Modified

Calcium - metabolism

Thermoreceptors - cytology

Electrophysiology

Behavior, Animal - physiology

Neurons, Afferent - physiology

Recombinant Fusion Proteins - metabolism

Thermoreceptors - physiology

Animals

Recombinant Fusion Proteins - genetics

Larva - physiology

Drosophila melanogaster

Fluorescent Dyes

Details

Title: Subtitle: Identification and function of thermosensory neurons in Drosophila larvae
Creators: Lei Liu - Department of Internal Medicine, University of Iowa, Roy J. and Lucille A. Carver College of Medicine, 500 EMRB, Iowa City, Iowa 52242, USA
Olena Yermolaieva
Wayne A Johnson
Francois M Abboud
Michael J Welsh
Resource Type: Journal article
Publication Details: Nature neuroscience, Vol.6(3), pp.267-273
Publisher: United States
DOI: 10.1038/nn1009
PMID: 12563263
ISSN: 1097-6256
eISSN: 1546-1726
Grant note: DK25295 / NIDDK NIH HHS HL14388 / NHLBI NIH HHS
Language: English
Date published: 03/2003
Academic Unit: Neurology; Molecular Physiology and Biophysics; Pulmonary, Critical Care, and Occupational Medicine; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Neurosurgery; Internal Medicine
Record Identifier: 9984020614602771

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