Journal article
Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31
Nature communications, Vol.4(1), pp.1627-1627
2013
DOI: 10.1038/ncomms2613
PMCID: PMC3709460
PMID: 23535648
Abstract
Epithelial ovarian cancer (EOC) has a heritable component that remains to be fully characterized. Most identified common susceptibility variants lie in non-protein-coding sequences. We hypothesized that variants in the 3' untranslated region at putative microRNA (miRNA)-binding sites represent functional targets that influence EOC susceptibility. Here, we evaluate the association between 767 miRNA-related single-nucleotide polymorphisms (miRSNPs) and EOC risk in 18,174 EOC cases and 26,134 controls from 43 studies genotyped through the Collaborative Oncological Gene-environment Study. We identify several miRSNPs associated with invasive serous EOC risk (odds ratio=1.12, P=10(-8)) mapping to an inversion polymorphism at 17q21.31. Additional genotyping of non-miRSNPs at 17q21.31 reveals stronger signals outside the inversion (P=10(-10)). Variation at 17q21.31 is associated with neurological diseases, and our collaboration is the first to report an association with EOC susceptibility. An integrated molecular analysis in this region provides evidence for ARHGAP27 and PLEKHM1 as candidate EOC susceptibility genes.
Details
- Title: Subtitle
- Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31
- Creators
- Jennifer Permuth-Wey - Department of Cancer Epidemiology, Division of Population Sciences, Moffitt Cancer Center, Tampa, Florida, USA. Jenny.Wey@moffitt.orgKate LawrensonHoward C ShenAneliya VelkovaJonathan P TyrerZhihua ChenHui-Yi LinY Ann ChenYa-Yu TsaiXiaotao QuSusan J RamusRod KarevanJanet LeeNathan LeeMelissa C LarsonKatja K AbenHoda Anton-CulverNatalia AntonenkovaAntonis C AntoniouSebastian M ArmasuFrançois BacotLaura BagliettoElisa V BanderaJill Barnholtz-SloanMatthias W BeckmannMichael J BirrerGreg BloomNatalia BogdanovaLouise A BrintonAngela Brooks-WilsonRobert BrownRalf ButzowQiuyin CaiIan CampbellJenny Chang-ClaudeStephen ChanockGeorgia Chenevix-TrenchJin Q ChengMine S CicekGerhard A CoetzeeLinda S CookFergus J CouchDaniel W CramerJulie M CunninghamAgnieszka Dansonka-MieszkowskaEvelyn DespierreJennifer A DohertyThilo DörkAndreas du BoisMatthias DürstDouglas F EastonDiana EcclesRobert EdwardsArif B EkiciPeter A FaschingDavid A FenstermacherJames M FlanaganMontserrat Garcia-ClosasAleksandra Gentry-MaharajGraham G GilesRosalind M GlasspoolJesus Gonzalez-BosquetMarc T GoodmanMartin GoreBohdan GórskiJacek GronwaldPer HallMari K HallePhilipp HarterFlorian HeitzPeter HillemannsMaureen HoatlinClaus K HøgdallEstrid HøgdallSatoyo HosonoAnna JakubowskaAllan JensenHeather JimKimberly R KalliBeth Y KarlanStanley B KayeLinda E KelemenLambertus A KiemeneyFumitaka KikkawaGottfried E KonecnyCamilla KrakstadSusanne Krüger KjaerJolanta KupryjanczykDiether LambrechtsSandrina LambrechtsJohnathan M LancasterNhu D LeArto LeminenDouglas A LevineDong LiangBoon Kiong LimJolanta LissowskaKaren H LuJan LubińskiGalina LurieLeon F A G MassugerKeitaro MatsuoValerie McGuireJohn R McLaughlinUsha MenonFrancesmary ModugnoKirsten B MoysichToru NakanishiSteven A NarodLotte NedergaardRoberta B NessHeli NevanlinnaStefan NickelsHoutan NoushmehrKunle OdunsiSara H OlsonIrene OrlowJames PaulCeleste L PearceTanja PejovicLiisa M PelttariMalcolm C PikeElizabeth M PoolePaola RaskaStefan P RennerHarvey A RischLorna Rodriguez-RodriguezMary Anne RossingAnja RudolphIngo B RunnebaumIwona K RzepeckaHelga B SalvesenIra SchwaabGianluca SeveriViji ShridharXiao-Ou ShuYurii B ShvetsovWeiva SiehHonglin SongMelissa C SoutheyBeata SpiewankiewiczDaniel StramRebecca SutphenSoo-Hwang TeoKathryn L TerryDaniel C TessierPamela J ThompsonShelley S TworogerAnne M van AltenaIgnace VergoteRobert A VierkantDaniel VincentAllison F VitonisShan Wang-GohrkeRachel Palmieri WeberNicolas WentzensenAlice S WhittemoreElisabeth WikLynne R WilkensBoris WinterhoffYin Ling WooAnna H WuYong-Bing XiangHannah P YangWei ZhengArgyrios ZiogasFamida ZulkifliCatherine M PhelanEdwin IversenJoellen M SchildkrautAndrew BerchuckBrooke L FridleyEllen L GoodePaul D P PharoahAlvaro N A MonteiroThomas A SellersJie LinSimon A GaytherAustralian Ovarian Cancer Study (Contributor)
- Resource Type
- Journal article
- Publication Details
- Nature communications, Vol.4(1), pp.1627-1627
- Publisher
- England
- DOI
- 10.1038/ncomms2613
- PMID
- 23535648
- PMCID
- PMC3709460
- ISSN
- 2041-1723
- eISSN
- 2041-1723
- Grant note
- R03 CA113148 / NCI NIH HHS R01-CA017054 / NCI NIH HHS K22-CA138563 / NCI NIH HHS N01 CN025403 / NCI NIH HHS R01-CA122443 / NCI NIH HHS R37-CA070867 / NCI NIH HHS R37 CA070867 / NCI NIH HHS K22 CA138563 / NCI NIH HHS M01-RR000056 / NCRR NIH HHS 13086 / Cancer Research UK P30 CA071789 / NCI NIH HHS R01-CA067262 / NCI NIH HHS R01-CA050385 / NCI NIH HHS Intramural NIH HHS MSH-87734 / CIHR C490/A10124 / Cancer Research UK R01-CA074850 / NCI NIH HHS R01 CA067262 / NCI NIH HHS P50 CA105009 / NCI NIH HHS R01-CA114343-S1 / NCI NIH HHS R01-CA092044 / NCI NIH HHS R01-CA064277 / NCI NIH HHS R01 CA074850 / NCI NIH HHS R01 CA054419 / NCI NIH HHS R01 CA064277 / NCI NIH HHS R01-CA080978 / NCI NIH HHS R01-CA054419 / NCI NIH HHS R01 CA136924 / NCI NIH HHS R01 CA076016 / NCI NIH HHS P50-CA105009 / NCI NIH HHS K07 CA143047 / NCI NIH HHS MOP-86727 / CIHR P01-CA087696 / NCI NIH HHS R01 CA122443 / NCI NIH HHS R01-CA063678 / NCI NIH HHS 11022 / Cancer Research UK R01-CA061132 / NCI NIH HHS K07-CA095666 / NCI NIH HHS R01-CA014089 / NCI NIH HHS R01-CA058860 / NCI NIH HHS R01 CA058860 / NCI NIH HHS R01-CA126841 / NCI NIH HHS P30 CA015083 / NCI NIH HHS R01 CA106414 / NCI NIH HHS R01 CA149429 / NCI NIH HHS R01 CA114343 / NCI NIH HHS R01 CA087696 / NCI NIH HHS R01-CA114343 / NCI NIH HHS C490/A6187 / Cancer Research UK R01-CA087538 / NCI NIH HHS P30 CA076292 / NCI NIH HHS R01-CA076016 / NCI NIH HHS R01-CA136924 / NCI NIH HHS K07-CA143047 / NCI NIH HHS N01-PC067001 / NCI NIH HHS C536/A13086 / Cancer Research UK R01-CA016056 / NCI NIH HHS R01 CA126841 / NCI NIH HHS 10118 / Cancer Research UK P30 CA014089 / NCI NIH HHS R01-CA-114343 / NCI NIH HHS P01-CA017054 / NCI NIH HHS R03 CA115195 / NCI NIH HHS U01 CA069417 / NCI NIH HHS R01-CA080742 / NCI NIH HHS R01 CA063682 / NCI NIH HHS R01 CA058598 / NCI NIH HHS R01 CA128978 / NCI NIH HHS P01 CA017054 / NCI NIH HHS R01-CA83918 / NCI NIH HHS R01 CA080742 / NCI NIH HHS K07-CA80668 / NCI NIH HHS R01 CA083918 / NCI NIH HHS R03-CA115195 / NCI NIH HHS R01-CA058598 / NCI NIH HHS K07 CA092044 / NCI NIH HHS R01-CA149429 / NCI NIH HHS N01-PC035137 / NCI NIH HHS P30 CA016056 / NCI NIH HHS C536/A6689 / Cancer Research UK 076113 / Wellcome Trust U01-CA069417 / NCI NIH HHS 11174 / Cancer Research UK R01 CA087538 / NCI NIH HHS R01-CA071766 / NCI NIH HHS R01-CA106414 / NCI NIH HHS R01-CA049449 / NCI NIH HHS U19-CA148112 / NCI NIH HHS C490/A10119 / Cancer Research UK P50-CA136393 / NCI NIH HHS K07 CA095666 / NCI NIH HHS N01PC35137 / NCI NIH HHS R01 CA112523 / NCI NIH HHS 10124 / Cancer Research UK N01-CN25403 / NCI NIH HHS U19 CA148112 / NCI NIH HHS N01-CN55424 / NCI NIH HHS R01-CA061107 / NCI NIH HHS R01 CA050385 / NCI NIH HHS R01-095023 / PHS HHS P30 CA008748 / NCI NIH HHS U01-CA071966 / NCI NIH HHS P50 CA136393 / NCI NIH HHS P30-CA15083 / NCI NIH HHS R01 CA049449 / NCI NIH HHS R03-CA113148 / NCI NIH HHS R01-CA112523 / NCI NIH HHS
- Language
- English
- Date published
- 2013
- Academic Unit
- Epidemiology; Obstetrics and Gynecology
- Record Identifier
- 9983931895002771
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