Identification of Novel Fusion Transcripts in High Grade Serous Ovarian Cancer

Andreea Newtson; Henry Reyes; Eric J. Devor; Michael J. Goodheart; Jesus Gonzalez Bosquet

doi:10.3390/ijms22094791

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Identification of Novel Fusion Transcripts in High Grade Serous Ovarian Cancer

Journal article

Open access

Peer reviewed

Identification of Novel Fusion Transcripts in High Grade Serous Ovarian Cancer

Andreea Newtson, Henry Reyes, Eric J. Devor, Michael J. Goodheart and Jesus Gonzalez Bosquet

International journal of molecular sciences, Vol.22(9), p.4791

05/01/2021

DOI: 10.3390/ijms22094791

PMCID: PMC8125626

PMID: 33946483

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Abstract

Fusion genes are structural chromosomal rearrangements resulting in the exchange of DNA sequences between genes. This results in the formation of a new combined gene. They have been implicated in carcinogenesis in a number of different cancers, though they have been understudied in high grade serous ovarian cancer. This study used high throughput tools to compare the transcriptome of high grade serous ovarian cancer and normal fallopian tubes in the interest of identifying unique fusion transcripts within each group. Indeed, we found that there were significantly more fusion transcripts in the cancer samples relative to the normal fallopian tubes. Following this, the role of fusion transcripts in chemo-response and overall survival was investigated. This led to the identification of fusion transcripts significantly associated with overall survival. Validation was performed with different analytical platforms and different algorithms to find fusion transcripts.

Physical Sciences

Biochemistry & Molecular Biology

Chemistry

Chemistry, Multidisciplinary

Life Sciences & Biomedicine

Science & Technology

Details

Title: Subtitle: Identification of Novel Fusion Transcripts in High Grade Serous Ovarian Cancer
Creators: Andreea Newtson - University of Iowa
Henry Reyes - University at Buffalo, State University of New York
Eric J. Devor - University of Iowa Hospitals and Clinics
Michael J. Goodheart - University of Iowa Hospitals and Clinics
Jesus Gonzalez Bosquet - Univ Iowa Hosp & Clin, Div Gynecol Oncol, Dept Obstet & Gynecol, Iowa City, IA 52242 USA
Resource Type: Journal article
Publication Details: International journal of molecular sciences, Vol.22(9), p.4791
DOI: 10.3390/ijms22094791
PMID: 33946483
PMCID: PMC8125626
NLM abbreviation: Int J Mol Sci
ISSN: 1661-6596
eISSN: 1422-0067
Publisher: Mdpi
Number of pages: 20
Grant note: American Association of Obstetricians and Gynecologists Foundation (AAOGF) Bridge Funding Award R01 CA99908; R01 CA184101 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Department of Obstetrics & Gynecology at the University of Iowa
Language: English
Date published: 05/01/2021
Academic Unit: Obstetrics and Gynecology
Record Identifier: 9984318228602771

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