Journal article
Identification of Predictive Pathways for Non-Hodgkin Lymphoma Prognosis
Cancer informatics, Vol.9(9), pp.281-292
12/07/2010
DOI: 10.4137/CIN.S6315
PMCID: PMC3021201
PMID: 21245948
Abstract
Despite decades of intensive research, NHL (non-Hodgkin lymphoma) still remains poorly understood and is largely incurable. Recent molecular studies suggest that genomic variants measured with SNPs (single nucleotide polymorphisms) in genes may have additional predictive power for NHL prognosis beyond clinical risk factors. We analyzed a genetic association study. The prognostic cohort consisted of 346 patients, among whom 138 had DLBCL (diffuse large B-cell lymphoma) and 101 had FL ( follicular lymphoma). For DLBCL, we analyzed 1229 SNPs which represented 122 KEGG pathways. For FL, we analyzed 1228 SNPs which represented 122 KEGG pathways. Unlike in existing studies, we targeted at identifying pathways with significant additional predictive power beyond clinical factors. In addition, we accounted for the joint effects of multiple SNPs within pathways, whereas some existing studies drew pathway-level conclusions based on separate analysis of individual SNPs. For DLBCL, we identified four pathways, which, combined with the clinical factors, had medians of the prediction logrank statistics as 2.535, 2.220, 2.094, 2.453, and 2.512, respectively. As a comparison, the clinical factors had a median of the prediction logrank statistics around 0.552. For FL, we identified two pathways, which, combined with the clinical factors, had medians of the prediction logrank statistics as 4.320 and 3.532, respectively. As a comparison, the clinical factors had a median of the prediction logrank statistics around 1.212. For NHL overall, we identified three pathways, which, combined with the clinical factors, had medians of the prediction logrank statistics as 5.722, 5.314, and 5.441, respective. As a comparison, the clinical factors had a median of the prediction logrank statistics around 4.411. The identified pathways have sound biological bases. In addition, they are different from those identified using existing approaches. They may provide further insights into the biological mechanisms underlying the prognosis of NHL.
Details
- Title: Subtitle
- Identification of Predictive Pathways for Non-Hodgkin Lymphoma Prognosis
- Creators
- Xuesong Han - University of North Carolina at Chapel HillYang Li - Yale UniversityJian Huang - University of IowaYawei Zhang - Yale UniversityTheodore Holford - Yale UniversityQing Lan - National Institutes of HealthNathaniel Rothman - National Institutes of HealthTongzhang Zheng - Yale UniversityMichael R Kosorok - University of North Carolina at Chapel HillShuangge Ma - Yale University
- Resource Type
- Journal article
- Publication Details
- Cancer informatics, Vol.9(9), pp.281-292
- Publisher
- Libertas Academica
- DOI
- 10.4137/CIN.S6315
- PMID
- 21245948
- PMCID
- PMC3021201
- ISSN
- 1176-9351
- eISSN
- 1176-9351
- Language
- English
- Date published
- 12/07/2010
- Academic Unit
- Statistics and Actuarial Science
- Record Identifier
- 9984257746502771
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