Identification of Regional Mechanical Anisotropy in Soft Tissue Analogs

Ramesh RAGHUPATHY; Colleen WITZENBURG; Spencer P LAKE; Edward A SANDER; Victor H BAROCAS

doi:10.1115/1.4005170

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Identification of Regional Mechanical Anisotropy in Soft Tissue Analogs

Journal article

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Peer reviewed

Identification of Regional Mechanical Anisotropy in Soft Tissue Analogs

Ramesh RAGHUPATHY, Colleen WITZENBURG, Spencer P LAKE, Edward A SANDER and Victor H BAROCAS

Journal of biomechanical engineering, Vol.133(9), pp.091011-091011

2011

DOI: 10.1115/1.4005170

PMCID: PMC3705984

PMID: 22010746

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Abstract

In a previous work (Raghupathy and Barocas, 2010, “Generalized Anisotropic Inverse Mechanics for Soft Tissues,”J. Biomech. Eng., 132(8), pp. 081006), a generalized anisotropic inverse mechanics method applicable to soft tissues was presented and tested against simulated data. Here we demonstrate the ability of the method to identify regional differences in anisotropy from full-field displacements and boundary forces obtained from biaxial extension tests on soft tissue analogs. Tissue heterogeneity was evaluated by partitioning the domain into homogeneous subdomains. Tests on elastomer samples demonstrated the performance of the method on isotropic materials with uniform and nonuniform properties. Tests on fibroblast-remodeled collagen cruciforms indicated a strong correlation between local structural anisotropy (measured by polarized light microscopy) and the evaluated local mechanical anisotropy. The results demonstrate the potential to quantify regional anisotropic material behavior on an intact tissue sample.

Fundamental and applied biological sciences. Psychology

Biological and medical sciences

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Details

Title: Subtitle: Identification of Regional Mechanical Anisotropy in Soft Tissue Analogs
Creators: Ramesh RAGHUPATHY - Department of Mechanical Engineering, University of Minnesota, Minneapolis, MN 55455, United States
Colleen WITZENBURG - Department of Mechanical Engineering, University of Minnesota, Minneapolis, MN 55455, United States
Spencer P LAKE - Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, United States
Edward A SANDER - Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, United States
Victor H BAROCAS - Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, United States
Resource Type: Journal article
Publication Details: Journal of biomechanical engineering, Vol.133(9), pp.091011-091011
DOI: 10.1115/1.4005170
PMID: 22010746
PMCID: PMC3705984
NLM abbreviation: J Biomech Eng
ISSN: 0148-0731
eISSN: 1528-8951
Publisher: American Society of Mechanical Engineers; New York, NY
Language: English
Date published: 2011
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Orthopedics and Rehabilitation; Craniofacial Anomalies Research Center; Chemical and Biochemical Engineering
Record Identifier: 9984064223402771

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