Journal article
Identification of Two Proteins Required for Conjunction and Regular Segregation of Achiasmate Homologs in Drosophila Male Meiosis
Cell, Vol.123(4), pp.555-568
2005
DOI: 10.1016/j.cell.2005.08.043
PMID: 16286005
Abstract
In
Drosophila males, homologous chromosomes segregate by an unusual process involving physical connections not dependent on recombination. We have identified two meiotic proteins specifically required for this process. Stromalin in Meiosis (SNM) is a divergent member of the SCC3/SA/STAG family of cohesin proteins, and
Modifier of Mdg4 i
n Meiosis (MNM) is one of many BTB-domain proteins expressed from the
mod(mdg4) locus. SNM and MNM colocalize along with a repetitive rDNA sequence known to function as an X-Y pairing site to nucleolar foci during meiotic prophase and to a compact structure associated with the X-Y bivalent during prometaphase I and metaphase I. Additionally, MNM localizes to autosomal foci throughout meiosis I. These proteins are mutually dependent for their colocalization, and at least MNM requires the function of
teflon, another meiotic gene. SNM and MNM do not colocalize with SMC1, suggesting that the homolog conjunction mechanism is independent of cohesin.
Details
- Title: Subtitle
- Identification of Two Proteins Required for Conjunction and Regular Segregation of Achiasmate Homologs in Drosophila Male Meiosis
- Creators
- Sharon E Thomas - Department of Biochemistry, Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee 37996Morvarid Soltani-Bejnood - Genome Science and Technology Program, University of Tennessee, Knoxville, Tennessee 37996Peggy Roth - Institute of Genetics, Martin-Luther-University, Halle, GermanyRainer Dorn - Institute of Genetics, Martin-Luther-University, Halle, GermanyJohn M Logsdon - Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, Iowa 52242Bruce D McKee - Department of Biochemistry, Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee 37996
- Resource Type
- Journal article
- Publication Details
- Cell, Vol.123(4), pp.555-568
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.cell.2005.08.043
- PMID
- 16286005
- ISSN
- 0092-8674
- eISSN
- 1097-4172
- Language
- English
- Date published
- 2005
- Academic Unit
- Biology
- Record Identifier
- 9984217539502771
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