Identification of Ugandan HIV Type 1 Variants with Unique Patterns of Recombination in pol Involving Subtypes A and D

SUSAN H ESHLEMAN; MATTHEW J GONZALES; GRAZIELLA BECKER-PERGOLA; SHAWN C CUNNINGHAM; LAURA A GUAY; J. BROOKS JACKSON; ROBERT W SHAFER

doi:10.1089/088922202317406655

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Identification of Ugandan HIV Type 1 Variants with Unique Patterns of Recombination in pol Involving Subtypes A and D

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Identification of Ugandan HIV Type 1 Variants with Unique Patterns of Recombination in pol Involving Subtypes A and D

SUSAN H ESHLEMAN, MATTHEW J GONZALES, GRAZIELLA BECKER-PERGOLA, SHAWN C CUNNINGHAM, LAURA A GUAY, J. BROOKS JACKSON and ROBERT W SHAFER

AIDS research and human retroviruses, Vol.18(7), pp.507-511

05/01/2002

DOI: 10.1089/088922202317406655

PMCID: PMC2573392

PMID: 12015904

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Abstract

Most HIV-1 infections in Uganda are caused by subtypes A and D. The prevalence of recombination and the sites of specific breakpoints between these subtypes have not been reported. HIV-1 pol sequences encoding protease (amino acids 1-99) and reverse transcriptase (amino acids 1-324) from 102 pregnant Ugandan women were analyzed by the Recombinant Identification Program, SimPlot, and examination of phylogenetically informative sites to identify sites of recombination between sequence segments belonging to different subtypes. Thirteen percent (13 of 102) of the pol sequences contained strong evidence of recombination between subtypes A and D. At least nine different patterns of recombination were observed. Five women infected with a recombinant virus transmitted the recombinant virus perinatally. In this population-based study, intersubtype recombinants were common. The large number of different types of pol recombinants identified suggests that recombination occurs readily in the pol region. Perinatal transmission of the recombinant viruses demonstrates their evolutionary stability.

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Title: Subtitle: Identification of Ugandan HIV Type 1 Variants with Unique Patterns of Recombination in pol Involving Subtypes A and D
Creators: SUSAN H ESHLEMAN - Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205
MATTHEW J GONZALES - Division of Infectious Diseases, Stanford University, Stanford, California 94305
GRAZIELLA BECKER-PERGOLA - Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205
SHAWN C CUNNINGHAM - Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205
LAURA A GUAY - Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205
J. BROOKS JACKSON - Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205
ROBERT W SHAFER - Division of Infectious Diseases, Stanford University, Stanford, California 94305
Resource Type: Journal article
Publication Details: AIDS research and human retroviruses, Vol.18(7), pp.507-511
DOI: 10.1089/088922202317406655
PMID: 12015904
PMCID: PMC2573392
NLM abbreviation: AIDS Res Hum Retroviruses
ISSN: 0889-2229
eISSN: 1931-8405
Language: English
Date published: 05/01/2002
Academic Unit: Pathology; VPMA - Administration
Record Identifier: 9984047888402771

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