Journal article
Identification of a Gemcitabine-Warfarin Interaction
Pharmacotherapy : official journal of the American College of Clinical Pharmacy, Vol.19(11), pp.1331-1333
11/1999
DOI: 10.1592/phco.19.16.1331.30873
Abstract
A man anticoagulated with warfarin 57.5 mg/week (international normalized ratio [INR] 1.94) was diagnosed with nonsmall cell lung cancer and prescribed weekly gemcitabine. With the first dose of the first cycle, his INR rose to 3.52, and his weekly warfarin dose was decreased to 52.5 mg. The lower warfarin dose was continued during the 2-week rest period between cycles 1 and 2 of gemcitabine therapy, and his INR decreased to 2.08. The patient resumed gemcitabine while taking warfarin 52.5 mg/week; however, the warfarin dosage had to be reduced to 48.5 mg/week to achieve a therapeutic INR. After gemcitabine was discontinued, the patient was restabilized at the prechemotherapy baseline dosage. We conclude that an interaction between warfarin and gemcitabine occurred with the first dose of the latter and recommend weekly INRs for anticoagulated patients receiving gemcitabine.
Details
- Title: Subtitle
- Identification of a Gemcitabine-Warfarin Interaction
- Creators
- Shilpa A. Kinikar - University of Wisconsin–MadisonJill M. Kolesar - University of Wisconsin–Madison
- Resource Type
- Journal article
- Publication Details
- Pharmacotherapy : official journal of the American College of Clinical Pharmacy, Vol.19(11), pp.1331-1333
- Publisher
- Blackwell Publishing Ltd; Oxford, UK
- DOI
- 10.1592/phco.19.16.1331.30873
- ISSN
- 0277-0008
- eISSN
- 1875-9114
- ISSN
- 0277-0008
- eISSN
- 1875-9114
- Number of pages
- 3
- Language
- English
- Date published
- 11/1999
- Academic Unit
- Pharmacy; Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984695792402771
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