Journal article
Identification of a Paracrine Signaling Mechanism Linking CD34(high) Progenitors to the Regulation of Visceral Fat Expansion and Remodeling
Cell reports (Cambridge), Vol.29(2), p.270
10/08/2019
DOI: 10.1016/j.celrep.2019.08.092
PMCID: PMC10950319
PMID: 31597091
Abstract
Accumulation of visceral (VIS) is a predictor of metabolic disorders and insulin resistance. This is due in part to the limited capacity of VIS fat to buffer lipids allowing them to deposit in insulin-sensitive tissues. Mechanisms underlying selective hypertrophic growth and tissue remodeling properties of VIS fat are not well understood. We identified subsets of adipose progenitors (APs) unique to VIS fat with differential Cd34 expression and adipogenic capacity. VIS low (Cd34 low) APs are adipogenic, whereas VIS high (Cd34 high) APs are not. Furthermore, VIS high APs inhibit adipogenic differentiation of SUB and VIS low APs in vitro through the secretion of soluble inhibitory factor(s). The number of VIS high APs increased with adipose tissue expansion, and their abundance in vivo caused hypertrophic growth, fibrosis, inflammation, and metabolic dysfunction. This study unveils the presence of APs unique to VIS fat involved in the paracrine regulation of adipogenesis and tissue remodeling.
Details
- Title: Subtitle
- Identification of a Paracrine Signaling Mechanism Linking CD34(high) Progenitors to the Regulation of Visceral Fat Expansion and Remodeling
- Creators
- Marcio Buffolo - University of UtahKarla Maria Pires - University of UtahMaroua Ferhat - University of UtahOlesya Ilkun - University of UtahAman Makaju - Nora Eccles Harrison Cardiovascular Research and Training Institute, Salt Lake City, UT 84112, USAAlan Achenbach - University of UtahFaith Bowman - University of UtahDonald L. Atkinson - University of UtahWilliam L. Holland - University of UtahEz-Zoubir Amri - Institut de Biologie ValroseBhagirath Chaurasia - University of UtahSarah Franklin - Nora Eccles Harrison Cardiovascular Research and Training Institute, Salt Lake City, UT 84112, USASihem Boudina - University of Utah
- Resource Type
- Journal article
- Publication Details
- Cell reports (Cambridge), Vol.29(2), p.270
- DOI
- 10.1016/j.celrep.2019.08.092
- PMID
- 31597091
- PMCID
- PMC10950319
- NLM abbreviation
- Cell Rep
- ISSN
- 2211-1247
- eISSN
- 2211-1247
- Publisher
- Elsevier
- Number of pages
- 18
- Grant note
- 16GRNT30990018; 15POST25360014 / American Heart Association (AHA); American Heart Association T32DK091317 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) R01DK098646; R01DK100826 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Language
- English
- Date published
- 10/08/2019
- Academic Unit
- Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984359853702771
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