Identification of a new prostate cancer susceptibility locus on chromosome 8q24

Meredith Yeager; Nilanjan Chatterjee; Julia Ciampa; Kevin B Jacobs; Jesus Gonzalez-Bosquet; Richard B Hayes; Peter Kraft; Sholom Wacholder; Nick Orr; Sonja Berndt; Kai Yu; Amy Hutchinson; Zhaoming Wang; Laufey Amundadottir; Heather Spencer Feigelson; Michael J Thun; W Ryan Diver; Demetrius Albanes; Jarmo Virtamo; Stephanie Weinstein; Fredrick R Schumacher; Geraldine Cancel-Tassin; Olivier Cussenot; Antoine Valeri; Gerald L Andriole; E David Crawford; Christopher A Haiman; Brian Henderson; Laurence Kolonel; Loic Le Marchand; Afshan Siddiq; Elio Riboli; Timothy J Key; Rudolf Kaaks; William Isaacs; Sarah Isaacs; Kathleen E Wiley; Henrik Gronberg; Fredrik Wiklund; Pär Stattin; Jianfeng Xu; S Lilly Zheng; Jielin Sun; Lars J Vatten; Kristian Hveem; Merethe Kumle; Margaret Tucker; Daniela S Gerhard; Robert N Hoover; Joseph F Fraumeni Jr; David J Hunter; Gilles Thomas; Stephen J Chanock

doi:10.1038/ng.444

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Identification of a new prostate cancer susceptibility locus on chromosome 8q24

Journal article

Peer reviewed

Identification of a new prostate cancer susceptibility locus on chromosome 8q24

Meredith Yeager, Nilanjan Chatterjee, Julia Ciampa, Kevin B Jacobs, Jesus Gonzalez-Bosquet, Richard B Hayes, Peter Kraft, Sholom Wacholder, Nick Orr, Sonja Berndt, …

Nature genetics, Vol.41(10), pp.1055-1057

10/2009

DOI: 10.1038/ng.444

PMCID: PMC3430510

PMID: 19767755

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Abstract

We report a genome-wide association study in 10,286 cases and 9,135 controls of European ancestry in the Cancer Genetic Markers of Susceptibility (CGEMS) initiative. We identify a new association with prostate cancer risk on chromosome 8q24 (rs620861, P = 1.3 x 10(-10), heterozygote OR = 1.17, 95% CI 1.10-1.24; homozygote OR = 1.33, 95% CI 1.21-1.45). This defines a new locus associated with prostate cancer susceptibility on 8q24.

Genetic Markers

European Continental Ancestry Group - genetics

Genome-Wide Association Study

Disease Susceptibility

Prostatic Neoplasms - genetics

Humans

Risk Factors

Genotype

Male

Chromosomes, Human, Pair 8

Polymorphism, Single Nucleotide

Genome, Human

Details

Title: Subtitle: Identification of a new prostate cancer susceptibility locus on chromosome 8q24
Creators: Meredith Yeager - Core Genotyping Facility, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland, USA. yeagerm@mail.nih.gov
Nilanjan Chatterjee
Julia Ciampa
Kevin B Jacobs
Jesus Gonzalez-Bosquet
Richard B Hayes
Peter Kraft
Sholom Wacholder
Nick Orr
Sonja Berndt
Kai Yu
Amy Hutchinson
Zhaoming Wang
Laufey Amundadottir
Heather Spencer Feigelson
Michael J Thun
W Ryan Diver
Demetrius Albanes
Jarmo Virtamo
Stephanie Weinstein
Fredrick R Schumacher
Geraldine Cancel-Tassin
Olivier Cussenot
Antoine Valeri
Gerald L Andriole
E David Crawford
Christopher A Haiman
Brian Henderson
Laurence Kolonel
Loic Le Marchand
Afshan Siddiq
Elio Riboli
Timothy J Key
Rudolf Kaaks
William Isaacs
Sarah Isaacs
Kathleen E Wiley
Henrik Gronberg
Fredrik Wiklund
Pär Stattin
Jianfeng Xu
S Lilly Zheng
Jielin Sun
Lars J Vatten
Kristian Hveem
Merethe Kumle
Margaret Tucker
Daniela S Gerhard
Robert N Hoover
Joseph F Fraumeni Jr
David J Hunter
Gilles Thomas
Stephen J Chanock
Resource Type: Journal article
Publication Details: Nature genetics, Vol.41(10), pp.1055-1057
DOI: 10.1038/ng.444
PMID: 19767755
PMCID: PMC3430510
NLM abbreviation: Nat Genet
ISSN: 1061-4036
eISSN: 1546-1718
Publisher: United States
Grant note: G0501019 / Medical Research Council Z01 CP010152-09 / Intramural NIH HHS HHSN261200800001C / CCR NIH HHS Z99 CA999999 / Intramural NIH HHS CA129684 / NCI NIH HHS ZIC CP010178-08 / Intramural NIH HHS CA131338 / NCI NIH HHS R01 CA129684 / NCI NIH HHS HHSN261200800001E / PHS HHS ZIA CP010152-11 / Intramural NIH HHS R01 CA131338 / NCI NIH HHS HHSN261200800001E / NCI NIH HHS
Language: English
Date published: 10/2009
Academic Unit: Obstetrics and Gynecology
Record Identifier: 9983931731502771

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