Journal article
Identification of diminished tissue culture invasiveness among multiple antibiotic resistant Salmonella typhimurium DT104
Microbial pathogenesis, Vol.28(1), pp.37-44
01/2000
DOI: 10.1006/mpat.1999.0322
PMID: 10623562
Abstract
Salmonella infections continue to cause gastrointestinal and systemic disease throughout the world. Salmonella typhimurium further poses a major health concern due to its apparent enhanced ability to acquire multiple antibiotic resistance genes. Currently it is unclear if multiresistant S. typhimurium are more or less pathogenic than non-resistant counterparts. Using an in vitro invasion assay, we evaluated the relative pathogenicity of over 400 multiresistant S. typhimurium isolates. Our studies failed to identify any ««hyperinvasive»» isolates. However, we identified 12 isolates exhibiting invasive phenotypes that were constrained relative to controls. These ««hypoinvasive»» strains were found in a variety of phagetypes all possessing at least a hexaresistant profile. Further studies revealed that the alterations in invasion were not due to changes in adherence. Limited studies exploringin vivo virulence revealed a mildly decreased ability to cause murine lethality for the hypoinvasive strain examined. These results indicate that the ability to cause disease is not increased but is rather mildly attenuated for certain isolates of multiresistant S. typhimurium.
Details
- Title: Subtitle
- Identification of diminished tissue culture invasiveness among multiple antibiotic resistant Salmonella typhimurium DT104
- Creators
- Steve A Carlson - Enteric Diseases and Food Safety Research, National Animal Disease Center, USDA, Agricultural Research Service, Ames, IA, 50010, USAMatt Browning - Department of Microbiology, University of Iowa College of Medicine, Iowa City, IA, 52242, USAKathleen E Ferris - Diagnostic Bacteriology Laboratory, National Veterinary Services Laboratories, USDA, Animal and Plant Health Inspection Service, Ames, IA, 50010, USABradley D Jones - Department of Microbiology, University of Iowa College of Medicine, Iowa City, IA, 52242, USA
- Resource Type
- Journal article
- Publication Details
- Microbial pathogenesis, Vol.28(1), pp.37-44
- Publisher
- Elsevier Ltd
- DOI
- 10.1006/mpat.1999.0322
- PMID
- 10623562
- ISSN
- 0882-4010
- eISSN
- 1096-1208
- Language
- English
- Date published
- 01/2000
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984083887402771
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