Journal article
Identification of diverse HIV type 1 subtypes and dual HIV type 1 infection in pregnant Ugandan women
AIDS research and human retroviruses, Vol.16(12), pp.1099-1104
2000
DOI: 10.1089/088922200414938
PMID: 10954884
Abstract
Vertical (mother-to-child) transmission accounts for the majority of pediatric HIV-1 infections. Many factors are involved in vertical transmission, however it is not clear which factors are most important for determining whether a mother will transmit HIV-1 to her infant. It has been suggested that HIV-1 subtype may influence vertical transmission and that subtype D viruses may be less likely to be transmitted in this setting. We analyzed HIV-1 gp120 V3 region sequences from the plasma of 20 pregnant Ugandan women of known transmission status who did not receive antiretroviral prophylaxis. V3 regions were cloned, sequenced, and subtyped by phylogenetic analysis. Among 11 women who transmitted HIV-1 to their infants, we detected subtypes A, C, D, and G. Two of the transmitters had dual infection with subtypes A and D. In addition, a third was infected with two distinct strains of subtype G viruses. HIV-1 subtype A and D viruses were found in 9 women who did not transmit the virus to their infants. This study reveals that pregnant Ugandan women harbor diverse HIV-1 subtypes, including women who transmit HIV-1 to their infants. Transmission of HIV1 with subtype D V3 regions was confirmed in 4 of the 11 transmitters, including 2 who had dual infection with subtype A and D HIV-1.
Details
- Title: Subtitle
- Identification of diverse HIV type 1 subtypes and dual HIV type 1 infection in pregnant Ugandan women
- Creators
- G BECKER-PERGOLA - Department of Pathology, Johns Hopkins University, Baltimore, Maryland 21205, United StatesJ. L MELLQUIST - Department of Pathology, Johns Hopkins University, Baltimore, Maryland 21205, United StatesL GUAY - Department of Pathology, Johns Hopkins University, Baltimore, Maryland 21205, United StatesF MMIRO - Makerere University Medical School, Kampala, UgandaC NDUGWA - Makerere University Medical School, Kampala, UgandaP KATAAHA - Makerere University Medical School, Kampala, UgandaJ. B JACKSON - Department of Pathology, Johns Hopkins University, Baltimore, Maryland 21205, United StatesS. H ESHLEMAN - Department of Pathology, Johns Hopkins University, Baltimore, Maryland 21205, United States
- Resource Type
- Journal article
- Publication Details
- AIDS research and human retroviruses, Vol.16(12), pp.1099-1104
- Publisher
- Liebert; Larchmont, NY
- DOI
- 10.1089/088922200414938
- PMID
- 10954884
- ISSN
- 0889-2229
- eISSN
- 1931-8405
- Language
- English
- Date published
- 2000
- Academic Unit
- Pathology; VPMA - Administration
- Record Identifier
- 9984047658502771
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