Journal article
Identification of new genetic risk variants for type 2 diabetes
PLoS genetics, Vol.6(9), pp.e1001127-e1001127
09/16/2010
DOI: 10.1371/journal.pgen.1001127
PMCID: PMC2940731
PMID: 20862305
Abstract
Although more than 20 genetic susceptibility loci have been reported for type 2 diabetes (T2D), most reported variants have small to moderate effects and account for only a small proportion of the heritability of T2D, suggesting that the majority of inter-person genetic variation in this disease remains to be determined. We conducted a multistage, genome-wide association study (GWAS) within the Asian Consortium of Diabetes to search for T2D susceptibility markers. From 590,887 SNPs genotyped in 1,019 T2D cases and 1,710 controls selected from Chinese women in Shanghai, we selected the top 2,100 SNPs that were not in linkage disequilibrium (r(2)<0.2) with known T2D loci for in silico replication in three T2D GWAS conducted among European Americans, Koreans, and Singapore Chinese. The 5 most promising SNPs were genotyped in an independent set of 1,645 cases and 1,649 controls from Shanghai, and 4 of them were further genotyped in 1,487 cases and 3,316 controls from 2 additional Chinese studies. Consistent associations across all studies were found for rs1359790 (13q31.1), rs10906115 (10p13), and rs1436955 (15q22.2) with P-values (per allele OR, 95%CI) of 6.49 × 10(-9) (1.15, 1.10-1.20), 1.45 × 10(-8) (1.13, 1.08-1.18), and 7.14 × 10(-7) (1.13, 1.08-1.19), respectively, in combined analyses of 9,794 cases and 14,615 controls. Our study provides strong evidence for a novel T2D susceptibility locus at 13q31.1 and the presence of new independent risk variants near regions (10p13 and 15q22.2) reported by previous GWAS.
Details
- Title: Subtitle
- Identification of new genetic risk variants for type 2 diabetes
- Creators
- Xiao Ou Shu - Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. xiao-ou.shu@vanderbilt.eduJirong LongQiuyin CaiLu Qi - Harvard Medical SchoolYong-Bing XiangYoon Shin ChoE Shyong TaiXu Lin - Shanghai Institutes for Biological SciencesWong-Ho ChowMin Jin GoMark SeielstadWei BaoHuaixing Li - Shanghai Institutes for Biological SciencesMarilyn C CornelisKai YuWanqing WenJiajun ShiBok-Ghee HanXue Ling SimLiegang LiuQibin QiHyung-Lae KimDaniel P K NgJong-Young LeeYoung Jin KimYu-Tang Gao - Shanghai Cancer InstituteWei ZhengXiangyang Li - Huazhong University of Science and TechnologyChun Li - Vanderbilt University School of MedicineFrank B Hu
- Resource Type
- Journal article
- Publication Details
- PLoS genetics, Vol.6(9), pp.e1001127-e1001127
- DOI
- 10.1371/journal.pgen.1001127
- PMID
- 20862305
- PMCID
- PMC2940731
- NLM abbreviation
- PLoS Genet
- ISSN
- 1553-7390
- eISSN
- 1553-7404
- Publisher
- United States
- Grant note
- R01CA122756 / NCI NIH HHS\r\nR01 CA064277 / NCI NIH HHS\r\nUL1 RR024975 / NCRR NIH HHS\r\nR37 CA070867 / NCI NIH HHS\r\nR01 DK091718 / NIDDK NIH HHS\r\nR01 CA118229 / NCI NIH HHS\r\nR01 CA090899 / NCI NIH HHS\r\nR01 CA100374 / NCI NIH HHS\r\nR01 CA122756 / NCI NIH HHS\r\n1 UL1 RR024975 / NCRR NIH HHS\r\nP30 CA68485 / NCI NIH HHS\r\nHG004399 / NHGRI NIH HHS\r\nR01CA92585 / NCI NIH HHS\r\nP30 CA068485 / NCI NIH HHS\r\nR01CA124558 / NCI NIH HHS\r\nR01CA100374 / NCI NIH HHS\r\nR37CA70867 / NCI NIH HHS\r\nR01CA64277 / NCI NIH HHS\r\nR01 DK058845 / NIDDK NIH HHS\r\nDK58845 / NIDDK NIH HHS\r\nU01 HG004399 / NHGRI NIH HHS\r\nR01 CA092585 / NCI NIH HHS\r\nR01 CA124558 / NCI NIH HHS\r\nR01CA90899 / NCI NIH HHS
- Language
- English
- Date published
- 09/16/2010
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9983996097702771
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