Identification of pathogens from the upper respiratory tract of adult emergency department patients at high risk for influenza complications in a pre-Sars-CoV-2 environment

Justin Hardick; Kathryn Shaw-Saliba; Breana McBryde; Charlotte A. Gaydos; Yu-Hsiang Hsieh; Frank Lovecchio; Mark Steele; David Talan; Richard E. Rothman; Emergency Department National Network Influenza Investigators

doi:10.1016/j.diagmicrobio.2021.115352

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Identification of pathogens from the upper respiratory tract of adult emergency department patients at high risk for influenza complications in a pre-Sars-CoV-2 environment

Journal article

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Identification of pathogens from the upper respiratory tract of adult emergency department patients at high risk for influenza complications in a pre-Sars-CoV-2 environment

Justin Hardick, Kathryn Shaw-Saliba, Breana McBryde, Charlotte A. Gaydos, Yu-Hsiang Hsieh, Frank Lovecchio, Mark Steele, David Talan, Richard E. Rothman and Emergency Department National Network Influenza Investigators

Diagnostic microbiology and infectious disease, Vol.100(2), pp.115352-115352

02/17/2021

DOI: 10.1016/j.diagmicrobio.2021.115352

PMCID: PMC8107121

PMID: 33639376

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Abstract

The emergence of SARS-CoV-2 and subsequent COVID-19 pandemic highlights the morbidity and potential disease severity caused by respiratory viruses. To elucidate pathogen prevalence, etiology of coinfections and URIs from symptomatic adult Emergency department patients in a pre-SARS-CoV-2 environment, we evaluated specimens from four geographically diverse Emergency departments in the United States from 2013–2014 utilizing ePlex RP RUO cartridges (Genmark Diagnostics). The overall positivity was 30.1% (241/799), with 6.6% (16/241) coinfections. Noninfluenza pathogens from most to least common were rhinovirus/ enterovirus, coronavirus, human metapneumovirus and RSV, respectively. Broad differences in disease prevalence and pathogen distributions were observed across geographic regions; the site with the highest detection rate (for both mono and coinfections) demonstrated the greatest pathogen diversity. A variety of respiratory pathogens and geographic variations in disease prevalence and copathogen type were observed. Further research is required to evaluate the clinical relevance of these findings, especially considering the SARS-CoV-2 pandemic and related questions regarding SARS-CoV-2 disease severity and the presence of coinfections.

Influenza

Coinfections

Emergency department

Multiplex diagnostics

Respiratory infections

Details

Title: Subtitle: Identification of pathogens from the upper respiratory tract of adult emergency department patients at high risk for influenza complications in a pre-Sars-CoV-2 environment
Creators: Justin Hardick - Johns Hopkins Medicine
Kathryn Shaw-Saliba - Johns Hopkins Medicine
Breana McBryde - Johns Hopkins Medicine
Charlotte A. Gaydos - Johns Hopkins Medicine
Yu-Hsiang Hsieh - Johns Hopkins Medicine
Frank Lovecchio - Maricopa Medical Center
Mark Steele - Truman Medical Center
David Talan - University of California, Los Angeles
Richard E. Rothman - Johns Hopkins Medicine
Emergency Department National Network Influenza Investigators
Resource Type: Journal article
Publication Details: Diagnostic microbiology and infectious disease, Vol.100(2), pp.115352-115352
DOI: 10.1016/j.diagmicrobio.2021.115352
PMID: 33639376
PMCID: PMC8107121
NLM abbreviation: Diagn Microbiol Infect Dis
ISSN: 0732-8893
eISSN: 1879-0070
Grant note: DOI: 10.13039/100000060, name: NIAID; DOI: 10.13039/100012399, name: BARDA
Language: English
Date published: 02/17/2021
Academic Unit: Emergency Medicine; Internal Medicine
Record Identifier: 9984296980902771

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