Journal article
Identification of recurrent fusion genes across multiple cancer types
Scientific reports, Vol.9(1), pp.1074-1074
01/31/2019
DOI: 10.1038/s41598-019-38550-6
PMCID: PMC6355770
PMID: 30705370
Abstract
Chromosome changes are one of the hallmarks of human malignancies. Chromosomal rearrangement is frequent in human cancers. One of the consequences of chromosomal rearrangement is gene fusions in the cancer genome. We have previously identified a panel of fusion genes in aggressive prostate cancers. In this study, we showed that 6 of these fusion genes are present in 7 different types of human malignancies with variable frequencies. Among them, the CCNH-C5orf30 and TRMT11-GRIK2 gene fusions were found in breast cancer, colon cancer, non-small cell lung cancer, esophageal adenocarcinoma, glioblastoma multiforme, ovarian cancer and liver cancer, with frequencies ranging from 12.9% to 85%. In contrast, four other gene fusions (mTOR-TP53BP1, TMEM135-CCDC67, KDM4-AC011523.2 and LRRC59-FLJ60017) are less frequent. Both TRMT11-GRIK2 and CCNH-C5orf30 are also frequently present in lymph node metastatic cancer samples from the breast, colon and ovary. Thus, detecting these fusion transcripts may have significant biological and clinical implications in cancer patient management.
Details
- Title: Subtitle
- Identification of recurrent fusion genes across multiple cancer types
- Creators
- Yan-Ping Yu - Departments of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USAPeng Liu - Departments of Biostatistics, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USAJoel Nelson - Departments of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USARonald L Hamilton - Departments of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USARohit Bhargava - Departments of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USAGeorge Michalopoulos - Departments of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USAQi Chen - Department of Pharmacology, Toxicology & Therapeutics, University of Kansas, Kansas City, KS, 66160, USAJun Zhang - Department of Medicine, University of Iowa, Iowa City, Iowa, 52242, USADeqin Ma - Department of Pathology, University of Iowa, Iowa City, Iowa, 52242, USAArjun Pennathur - Departments of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USAJames Luketich - Departments of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USAMichael Nalesnik - Departments of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USAGeorge Tseng - Departments of Biostatistics, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USAJian-Hua Luo - Departments of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA. luoj@upmc.edu
- Resource Type
- Journal article
- Publication Details
- Scientific reports, Vol.9(1), pp.1074-1074
- DOI
- 10.1038/s41598-019-38550-6
- PMID
- 30705370
- PMCID
- PMC6355770
- NLM abbreviation
- Sci Rep
- ISSN
- 2045-2322
- eISSN
- 2045-2322
- Publisher
- England
- Grant note
- R56 CA229262 / NCI NIH HHS R01 CA098249 / NCI NIH HHS P30 CA086862 / NCI NIH HHS
- Language
- English
- Date published
- 01/31/2019
- Academic Unit
- Pathology; Internal Medicine
- Record Identifier
- 9984047753402771
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