Identification of the Î² cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes

Scott M Lieberman; Anne M Evans; Bingye Han; Toshiyuki Takaki; Yuliya Vinnitskaya; Jennifer A Caldwell; David V Serreze; Jeffrey Shabanowitz; Donald F Hunt; Stanley G Nathenson; Pere Santamaria; Teresa P DiLorenzo

doi:10.1073/pnas.0932778100

Back

Identification of the Î² cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes

Journal article

Open access

Peer reviewed

Identification of the Î² cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes

Scott M Lieberman, Anne M Evans, Bingye Han, Toshiyuki Takaki, Yuliya Vinnitskaya, Jennifer A Caldwell, David V Serreze, Jeffrey Shabanowitz, Donald F Hunt, Stanley G Nathenson, …

Proceedings of the National Academy of Sciences - PNAS, Vol.100(14), pp.8384-8388

07/08/2003

DOI: 10.1073/pnas.0932778100

PMCID: PMC166238

PMID: 12815107

Files and links (1)

url

https://doi.org/10.1073/pnas.0932778100View

Published (Version of record) Open Access

Abstract

Type 1 diabetes is an autoimmune disease in which autoreactive T cells attack and destroy the insulin-producing pancreatic β cells. CD8 + T cells are essential for this β cell destruction, yet their specific antigenic targets are largely unknown. Here, we reveal that the autoantigen targeted by a prevalent population of pathogenic CD8 + T cells in nonobese diabetic mice is islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP). Through tetramer technology, IGRP-reactive T cells are readily detected in islets and peripheral blood directly ex vivo . The human IGRP gene maps to a diabetes susceptibility locus, suggesting that IGRP also may be an antigen for pathogenic T cells in human type 1 diabetes and, thus, a new, potential target for diagnostic and therapeutic approaches.

Biological Sciences

Details

Title: Subtitle: Identification of the Î² cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes
Creators: Scott M Lieberman - Departments of
Anne M Evans - Departments of
Bingye Han - Departments of
Toshiyuki Takaki - Departments of
Yuliya Vinnitskaya - Departments of
Jennifer A Caldwell - Departments of
David V Serreze - Departments of
Jeffrey Shabanowitz - Departments of
Donald F Hunt - Departments of
Stanley G Nathenson - Departments of
Pere Santamaria - Departments of
Teresa P DiLorenzo - Departments of
Resource Type: Journal article
Publication Details: Proceedings of the National Academy of Sciences - PNAS, Vol.100(14), pp.8384-8388
DOI: 10.1073/pnas.0932778100
PMID: 12815107
PMCID: PMC166238
NLM abbreviation: Proc Natl Acad Sci U S A
ISSN: 0027-8424
eISSN: 1091-6490
Publisher: National Academy of Sciences
Language: English
Date published: 07/08/2003
Academic Unit: Stead Family Department of Pediatrics; Rheumatology, Allergy, and Immunology
Record Identifier: 9984093222402771

Metrics

10 Record Views

337 Times Cited - Web of Science