Journal article
Identification of ubiquitin ligases required for skeletal Muscle Atrophy
Science (American Association for the Advancement of Science), Vol.294(5547), pp.1704-1708
2001
DOI: 10.1126/science.1065874
PMID: 11679633
Abstract
Skeletal muscle adapts to decreases in activity and load by undergoing atrophy. To identify candidate molecular mediators of muscle atrophy, we performed transcript profiling. Although many genes were up-regulated in a single rat model of atrophy, only a small subset was universal in all atrophy models. Two of these genes encode ubiquitin ligases: Muscle RING Finger 1 (MuRF1), and a gene we designate Muscle Atrophy F-box(MAFbx), the latter being a member of the SCF family of E3 ubiquitin ligases. Overexpression of MAFbx in myotubes produced atrophy, whereas mice deficient in either MAFbx orMuRF1 were found to be resistant to atrophy. These proteins are potential drug targets for the treatment of muscle atrophy.
Details
- Title: Subtitle
- Identification of ubiquitin ligases required for skeletal Muscle Atrophy
- Creators
- Sue C Bodine - University of Iowa, Internal MedicineEsther Latres - Regeneron (United States)Zhen-Qiang Pan - Derald H. Ruttenberg Cancer Center, Mount Sinai School of Medicine, New York, NY, 10029-6574, United StatesDavid M Valenzuela - Regeneron (United States)Thomas M Dechiara - Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591-6707, United StatesTrevor N Stitt - Regeneron (United States)George D Yancopoulos - Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591-6707, United StatesDavid J Glass - Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591-6707, United StatesSusanne Baumhueter - Applied Biosystems, 850 Lincoln Center Drive, Foster City, CA 94404, United StatesVenus K.-M Lai - Regeneron (United States)Lorna Nunez - Regeneron (United States)Brian A Clarke - Regeneron (United States)William T Poueymirou - Regeneron (United States)Frank J Panaro - Regeneron (United States)Erqian NA - Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591-6707, United StatesKumar Dharmarajan - Regeneron (United States)
- Resource Type
- Journal article
- Publication Details
- Science (American Association for the Advancement of Science), Vol.294(5547), pp.1704-1708
- DOI
- 10.1126/science.1065874
- PMID
- 11679633
- NLM abbreviation
- Science
- ISSN
- 0036-8075
- eISSN
- 1095-9203
- Publisher
- American Association for the Advancement of Science
- Language
- English
- Date published
- 2001
- Academic Unit
- Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984209058302771
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