Identification of α-dystroglycan as a receptor for lymphocytic choriomeningitis virus and Lassa fever virus

Wei Cao; Michael D Henry; Persephone Borrow; Hiroki Yamada; John H Elder; Eugene V Ravkov; Stuart T Nichol; Richard W Compans; Kevin P Campbell; Michael B. A Oldstone

doi:10.1126/science.282.5396.2079

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Identification of α-dystroglycan as a receptor for lymphocytic choriomeningitis virus and Lassa fever virus

Journal article

Peer reviewed

Identification of α-dystroglycan as a receptor for lymphocytic choriomeningitis virus and Lassa fever virus

Wei Cao, Michael D Henry, Persephone Borrow, Hiroki Yamada, John H Elder, Eugene V Ravkov, Stuart T Nichol, Richard W Compans, Kevin P Campbell and Michael B. A Oldstone

Science (American Association for the Advancement of Science), Vol.282(5396), pp.2079-2081

1998

DOI: 10.1126/science.282.5396.2079

PMID: 9851928

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Abstract

A peripheral membrane protein that is interactive with lymphocytic choriomeningitis virus (LCMV) was purified from cells permissive to infection. Tryptic peptides from this protein were determined to be α-dystroglycan (α-DG). Several strains of LCMV and other arenaviruses, including Lassa fever virus (LFV), Oliveros, and Mobala, bound to purified α-DG protein. Soluble α-DG blocked both LCMV and LFV infection. Cells bearing a null mutation of the gene encoding DG were resistant to LCMV infection, and reconstitution of DG expression in null mutant cells restored susceptibility to LCMV infection. Thus, α-DG is a cellular receptor for both LCMV and LFV.

Microbiology

Virology

Fundamental and applied biological sciences. Psychology

Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains

Biological and medical sciences

Details

Title: Subtitle: Identification of α-dystroglycan as a receptor for lymphocytic choriomeningitis virus and Lassa fever virus
Creators: Wei Cao - Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States
Michael D Henry - Howard Hughes Medical Institute, Department of Physiology and Biophysics, University of Iowa College of Medicine, Iowa City, IA 52242, United States
Persephone Borrow - Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire, RG20 7NN, United Kingdom
Hiroki Yamada - Howard Hughes Medical Institute, Department of Physiology and Biophysics, University of Iowa College of Medicine, Iowa City, IA 52242, United States
John H Elder - Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States
Eugene V Ravkov - Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, United States
Stuart T Nichol - Center for Disease Control 1600 Clifton Road, NE, MSG14, Atlanta, GA 30333, United States
Richard W Compans - Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, United States
Kevin P Campbell - Howard Hughes Medical Institute, Department of Physiology and Biophysics, University of Iowa College of Medicine, Iowa City, IA 52242, United States
Michael B. A Oldstone - Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States
Resource Type: Journal article
Publication Details: Science (American Association for the Advancement of Science), Vol.282(5396), pp.2079-2081
Publisher: American Association for the Advancement of Science; Washington, DC
DOI: 10.1126/science.282.5396.2079
PMID: 9851928
ISSN: 0036-8075
eISSN: 1095-9203
Language: English
Date published: 1998
Academic Unit: Neurology; Molecular Physiology and Biophysics; Pathology; Iowa Neuroscience Institute; Radiation Oncology; Urology
Record Identifier: 9984068276602771

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