Journal article
Identifying a Genetic Link Between Lung Function and Psoriasis
Annals of human genetics, Vol.89(2-3), pp.89-95
05/2025
DOI: 10.1111/ahg.12587
PMID: 39718377
Abstract
IntroductionThe common genetic underpinnings of psoriasis and pulmonary comorbidities have yet to be explored.Material and MethodsIn this cross-sectional study, we investigated the single-nucleotide polymorphisms (SNPs) associated with psoriasis and their relationship with pulmonary function using data from the UK Biobank (UKBB) and the Vanderbilt University Medical Center Biobank (BioVU).ResultsOut of the 63 psoriasis-associated SNPs identified in previous genome-wide association studies within the European population, we successfully identified 53 SNPs, including proxy SNPs in UKBB database. Following adjustments using age and sex, 31 SNPs displayed statistically significant associations with psoriasis. Among these, 16 SNPs exhibited significant associations with forced expiratory volume in 1 s (FEV1), 14 with forced vital capacity (FVC), and 5 with the FEV1/FVC ratio in the UKBB. In the validation analysis using the BioVU database, 27 of the 31 psoriasis-associated SNPs were available for examination. Notably, the minor allele of SNP rs8016947 was confirmed to be significant, indicating a reduced risk for psoriasis and improved FEV1. Similarly, the minor alleles of SNPs rs17716942 and rs8016947 were associated with a reduced risk of psoriasis and enhanced FVC. However, none of the 5 SNPs significantly associated with the FEV1/FVC ratio in the UKBB displayed significance in the BioVU dataset.ConclusionThis study has unveiled genetic variants that bridge the realms of psoriasis and lung function. The genes associated with these variants, including IFIH1, Grancalcin gene (GCA), and NFKB inhibitor alpha gene (NFKBIA), regulate innate immune responses, which suggests that immunodysregulation, a central element in psoriasis pathogenesis, may also impact lung function, alluding to a "skin-lung axis."
Details
- Title: Subtitle
- Identifying a Genetic Link Between Lung Function and Psoriasis
- Creators
- Kazuya Tanimura - University of PittsburghMelinda C. Aldrich - Vanderbilt University Medical CenterJames Jaworski - Vanderbilt University Medical CenterJinchuan Xing - Rutgers, The State University of New JerseySatoshi Okawa - University of PittsburghDivay Chandra - University of PittsburghSeyed M. Nouraie - University of PittsburghToru Nyunoya - University of Pittsburgh
- Resource Type
- Journal article
- Publication Details
- Annals of human genetics, Vol.89(2-3), pp.89-95
- DOI
- 10.1111/ahg.12587
- PMID
- 39718377
- NLM abbreviation
- Ann Hum Genet
- ISSN
- 0003-4800
- eISSN
- 1469-1809
- Publisher
- Wiley
- Number of pages
- 7
- Grant note
- S10RR025141 / Vanderbilt University Medical Center's BioVU CX000105 / US Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Biomedical Laboratory Research; US Department of Veterans Affairs 60327 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01HL149719 / American Heart Association UL1TR002243; UL1TR000445; UL1RR024975 / CTSA; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS)
- Language
- English
- Date published
- 05/2025
- Academic Unit
- Internal Medicine
- Record Identifier
- 9985214105702771
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