Identifying components of the NF-κB pathway in the beneficial Euprymna scolopes-vibrio fischen light organ symbiosis

Michael S Goodson; Mila Kojadinovic; Joshua V Troll; Margaret J McFall-Ngai; Todd E Scheetz; Thomas L Casavant; M Bento Soares

doi:10.1128/AEM.71.11.6934-6946.2005

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Identifying components of the NF-κB pathway in the beneficial Euprymna scolopes-vibrio fischen light organ symbiosis

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Identifying components of the NF-κB pathway in the beneficial Euprymna scolopes-vibrio fischen light organ symbiosis

Michael S Goodson, Mila Kojadinovic, Joshua V Troll, Margaret J McFall-Ngai, Todd E Scheetz, Thomas L Casavant and M Bento Soares

Applied and Environmental Microbiology, Vol.71(11), pp.6934-6946

2005

DOI: 10.1128/AEM.71.11.6934-6946.2005

PMID: 16269728

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Abstract

The Toll/NF-kappaB pathway is a common, evolutionarily conserved innate immune pathway that modulates the responses of animal cells to microbe-associated molecular patterns (MAMPs). Because MAMPs have been implicated as critical elements in the signaling of symbiont-induced development, an expressed sequence tag library from the juvenile light organ of Euprymna scolopes was used to identify members of the Toll/NF-kappaB pathway. Full-length transcripts were identified by using 5' and 3' RACE PCR. Seven transcripts critical for MAMP-induced triggering of the Toll/NF-kappaB phosphorylation cascade have been identified, including receptors, signal transducers, and a transcription factor. Further investigations should elucidate the role of the Toll/NF-kappaB pathway in the initiation of the beneficial symbiosis between E. scolopes and Vibrio fischeri.

Details

Title: Subtitle: Identifying components of the NF-κB pathway in the beneficial Euprymna scolopes-vibrio fischen light organ symbiosis
Creators: Michael S Goodson
Mila Kojadinovic
Joshua V Troll
Margaret J McFall-Ngai
Todd E Scheetz
Thomas L Casavant
M Bento Soares
Resource Type: Journal article
Publication Details: Applied and Environmental Microbiology, Vol.71(11), pp.6934-6946
DOI: 10.1128/AEM.71.11.6934-6946.2005
PMID: 16269728
NLM abbreviation: Appl Environ Microbiol
ISSN: 0099-2240
eISSN: 1098-5336
Language: English
Date published: 2005
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Ophthalmology and Visual Sciences
Record Identifier: 9983979955902771

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