Journal article
Idiopathic Intracranial Hypertension
Continuum (Minneapolis, Minn.), Vol.25(5), pp.1289-1309
10/2019
DOI: 10.1212/CON.0000000000000770
PMID: 31584538
Abstract
Idiopathic intracranial hypertension is a syndrome of increased intracranial pressure of unclear etiology that most often occurs in obese women of childbearing age but can also occur in men, children, and older adults. This article reviews the diagnostic criteria, clinical features, neuroimaging findings, differential diagnosis, and management options for this condition.
Recent population studies have found that the annual incidence of idiopathic intracranial hypertension is increasing in association with obesity rates, whereas recent scientific studies indicate a possible role for androgen sex hormones and adipose tissue in the pathogenesis of the disease. Prospective clinical trials have demonstrated a role for weight loss, acetazolamide, and topiramate in the management of mild disease. A recently begun randomized multicenter trial of surgical interventions will provide insight into the indications for surgical intervention, optimal timing and choice of intervention, and long-term outcomes.
Idiopathic intracranial hypertension is a disorder producing symptoms and signs of increased intracranial pressure in the absence of an alternative cause. The main goals of treatment are to preserve visual function and alleviate symptoms, which can usually be achieved with a combination of weight loss, medical therapies, and surgical interventions depending on the severity of symptoms and vision loss, response to treatment, and subsequent clinical course.
Details
- Title: Subtitle
- Idiopathic Intracranial Hypertension
- Creators
- Matthew J Thurtell
- Resource Type
- Journal article
- Publication Details
- Continuum (Minneapolis, Minn.), Vol.25(5), pp.1289-1309
- DOI
- 10.1212/CON.0000000000000770
- PMID
- 31584538
- ISSN
- 1080-2371
- eISSN
- 1538-6899
- Language
- English
- Date published
- 10/2019
- Academic Unit
- Neurology; Ophthalmology and Visual Sciences
- Record Identifier
- 9984187025802771
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