Journal article
IgM and IgG Responses to Varicella-Zoster Virus p32/p36 Complex After Chickenpox and Zoster, Congenital and Subclinical Infections, and Vaccination
The Journal of infectious diseases, Vol.159(3), pp.444-451
03/1989
DOI: 10.1093/infdis/159.3.444
PMID: 2536788
Abstract
Varicella-zoster virus (VZV) directs the synthesis of a nonglycosylated polypeptide complex with two prominent species with relative molecular masses of 32 000 and 36 000; the p32/p36 complex is present in both the viral nucleocapsid and the nuclear matrix of the infected cell. We have now further characterized the humoral immune response of VZV-infected humans to this complex and established that it is a major viral antigen. Antibodies to VZV p32/p36 were detected in sera from patients with both primary VZV infection (chickenpox) and VZV reactivation (zoster); the response after zoster was more pronounced. When the IgM and IgG components of the immune response were distinguished, IgM to the viral nucleoproteins was observed following chickenpox and zoster and, to a lesser extent, in recipients of VZV vaccine. An IgM response to VZV p32 also was detected during intrauterine VZV infection and subclinical VZV infection.
Details
- Title: Subtitle
- IgM and IgG Responses to Varicella-Zoster Virus p32/p36 Complex After Chickenpox and Zoster, Congenital and Subclinical Infections, and Vaccination
- Creators
- David R Harper - Department of Virology, Medical College of St. Bartholomew's Hospital, London, United Kingdom, Iowa City, IowaCharles Grose - Department of Virology, Medical College of St. Bartholomew's Hospital, London, United Kingdom, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- The Journal of infectious diseases, Vol.159(3), pp.444-451
- Publisher
- The University of Chicago Press
- DOI
- 10.1093/infdis/159.3.444
- PMID
- 2536788
- ISSN
- 0022-1899
- eISSN
- 1537-6613
- Language
- English
- Date published
- 03/1989
- Academic Unit
- Stead Family Department of Pediatrics; Infectious Disease (Pediatrics)
- Record Identifier
- 9984093312002771
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