Illicit drug use and risk for USA300 methicillin-resistant Staphylococcus aureus infections with bacteremia

Kristen M Kreisel; J Kristie Johnson; O Colin Stine; Michelle D Shardell; Eli N Perencevich; Alan J Lesse; Fred M Gordin; Michael W Climo; Mary Claire Roghmann

doi:10.3201/eid1609.091802

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Illicit drug use and risk for USA300 methicillin-resistant Staphylococcus aureus infections with bacteremia

Journal article

Open access

Peer reviewed

Illicit drug use and risk for USA300 methicillin-resistant Staphylococcus aureus infections with bacteremia

Kristen M Kreisel, J Kristie Johnson, O Colin Stine, Michelle D Shardell, Eli N Perencevich, Alan J Lesse, Fred M Gordin, Michael W Climo and Mary Claire Roghmann

Emerging infectious diseases, Vol.16(9), pp.1419-1427

09/2010

DOI: 10.3201/eid1609.091802

PMCID: PMC3294968

PMID: 20735927

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Abstract

To assess the association of illicit drug use and USA300 methicillin-resistant Staphylococcus aureus (MRSA) bacteremia, a multicenter study was conducted at 4 Veterans Affairs medical centers during 2004-2008. The study showed that users of illicit drugs were more likely to have USA300 MRSA bacteremia (in contrast to bacteremia caused by other S. aureus strains) than were patients who did not use illicit drugs (adjusted relative risk 3.0; 95% confidence interval 1.9-4.4). The association of illicit drug use with USA300 MRSA bacteremia decreased over time (p = 0.23 for trend). Notably, the proportion of patients with USA300 MRSA bacteremia who did not use illicit drugs increased over time. This finding suggests that this strain has spread from users of illicit drugs to other populations.

Molecular Epidemiology

Epidemics

United States - epidemiology

Cross Infection - etiology

Humans

Middle Aged

Methicillin-Resistant Staphylococcus aureus - classification

Male

Bacteremia - microbiology

Cross Infection - transmission

Bacteremia - etiology

Female

Retrospective Studies

Staphylococcal Infections - microbiology

Methicillin-Resistant Staphylococcus aureus - genetics

Cross Infection - epidemiology

Risk Factors

Substance-Related Disorders - complications

Staphylococcal Infections - transmission

Staphylococcal Infections - epidemiology

Cross Infection - microbiology

Bacteremia - epidemiology

Aged

Methicillin-Resistant Staphylococcus aureus - isolation & purification

Bacteremia - transmission

Cohort Studies

Staphylococcal Infections - etiology

Details

Title: Subtitle: Illicit drug use and risk for USA300 methicillin-resistant Staphylococcus aureus infections with bacteremia
Creators: Kristen M Kreisel - Department of Epidemiology and Preventive Medicine, University of Maryland Baltimore, Baltimore, MD 21201, USA. kris03222001@yahoo.com
J Kristie Johnson
O Colin Stine
Michelle D Shardell
Eli N Perencevich
Alan J Lesse
Fred M Gordin
Michael W Climo
Mary Claire Roghmann
Resource Type: Journal article
Publication Details: Emerging infectious diseases, Vol.16(9), pp.1419-1427
DOI: 10.3201/eid1609.091802
PMID: 20735927
PMCID: PMC3294968
NLM abbreviation: Emerg Infect Dis
ISSN: 1080-6040
eISSN: 1080-6059
Publisher: United States
Grant note: M01 RR016500 / NCRR NIH HHS K12 RR023250-03 / NCRR NIH HHS K12 RR023250 / NCRR NIH HHS
Language: English
Date published: 09/2010
Academic Unit: Epidemiology; Internal Medicine
Record Identifier: 9983779295202771

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