Journal article
Image analysis of calcium release dynamics
Methods in molecular biology (Clifton, N.J.), Vol.468, pp.145-156
2008
DOI: 10.1007/978-1-59745-249-6_11
PMID: 19099252
Abstract
Many aspects of animal development are dependent on the dynamic release of calcium (Ca2+) ions. Although Ca2+ release within a cell is tightly controlled, how the release dynamics result in a specific biological output in embryonic development is less clear. The integration of pharmacological and molecular-genetic studies with in vivo imaging in zebrafish and Xenopus has linked endogenous Ca2+ release to the Wnt signaling network. Our data suggests that distinct Ca2+ release dynamics lead to antagonism of the developmentally important Wnt/beta-catenin pathway while sustained Ca2+ release modulates polarized cell movements.
Details
- Title: Subtitle
- Image analysis of calcium release dynamics
- Creators
- Christina M Freisinger - Department of Biology, University of Iowa, Iowa City, USADouglas W HoustonDiane C Slusarski
- Resource Type
- Journal article
- Publication Details
- Methods in molecular biology (Clifton, N.J.), Vol.468, pp.145-156
- Publisher
- United States
- DOI
- 10.1007/978-1-59745-249-6_11
- PMID
- 19099252
- ISSN
- 1064-3745
- eISSN
- 1940-6029
- Grant note
- R01 CA112369 / NCI NIH HHS
- Language
- English
- Date published
- 2008
- Academic Unit
- Iowa Neuroscience Institute; Biology
- Record Identifier
- 9983992100002771
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