Journal article
Image analysis reveals differences in tumor multinucleations in Black and White patients with human papillomavirus-associated oropharyngeal squamous cell carcinoma
Cancer, Vol.128(21), pp.3831-3842
11/01/2022
DOI: 10.1002/cncr.34446
PMCID: PMC9782693
PMID: 36066461
Abstract
Understanding biological differences between different racial groups of human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) patients, who have differences in terms of incidence, survival, and tumor morphology, can facilitate accurate prognostic biomarkers, which can help develop personalized treatment strategies.
This study evaluated whether there were morphologic differences between HPV-associated tumors from Black and White patients in terms of multinucleation index (MuNI), an image analysis-derived metric that measures density of multinucleated tumor cells within epithelial regions on hematoxylin-eosin images and previously has been prognostic in HPV-associated OPSCC patients. In this study, the authors specifically evaluated whether the same MuNI cutoff that was prognostic of overall survival (OS) and disease-free survival in their previous study, T
, is valid for Black and White patients, separately. We also evaluated population-specific cutoffs, T
for Blacks and T
for Whites, for risk stratification.
MuNI was statistically significantly different between Black (mean, 3.88e-4; median, 3.67e-04) and White patients (mean, 3.36e-04; median, 2.99e-04), with p = .0078. Using T
, MuNI was prognostic of OS in the entire population with hazard ratio (HR) of 1.71 (p = .002; 95% confidence interval [CI], 1.21-2.43) and in White patients with HR of 1.72 (p = .005; 95% CI, 1.18-2.51). Population-specific cutoff, T
, yielded improved HR of 1.77 (p = .003; 95% CI, 1.21-2.58) for White patients, whereas T
did not improve risk-stratification in Black patients with HR of 0.6 (p = .3; HR, 0.6; 95% CI, 0.2-1.80).
Histological difference between White and Black patient tumors in terms of multinucleated tumor cells suggests the need for considering population-specific prognostic biomarkers for personalized risk stratification strategies for HPV-associated OPSCC patients.
Details
- Title: Subtitle
- Image analysis reveals differences in tumor multinucleations in Black and White patients with human papillomavirus-associated oropharyngeal squamous cell carcinoma
- Creators
- Can F Koyuncu - The Wallace H. Coulter Department of Biomedical EngineeringReetoja Nag - The Wallace H. Coulter Department of Biomedical EngineeringCheng Lu - The Wallace H. Coulter Department of Biomedical EngineeringGermán Corredor - The Wallace H. Coulter Department of Biomedical EngineeringVidya S Viswanathan - The Wallace H. Coulter Department of Biomedical EngineeringVlad C Sandulache - Baylor College of MedicinePingfu Fu - Case Western Reserve UniversityKailin Yang - Cleveland ClinicQuintin Pan - Case Western Reserve UniversityZelin Zhang - Georgia Institute of TechnologyJun Xu - Nanjing University of Information Science and TechnologyDeborah J Chute - Cleveland ClinicWade L Thorstad - Washington University in St. LouisFarhoud Faraji - University of California, San DiegoJustin A Bishop - The University of Texas Southwestern Medical CenterMitra Mehrad - Vanderbilt University Medical CenterPatricia D Castro - Baylor College of MedicineAndrew G Sikora - Baylor College of MedicineLester D R Thompson - Southern California Permanente Medical Group, Pasadena, California, USARebecca D Chernock - Washington University in St. LouisKrystle A Lang Kuhs - Vanderbilt University Medical CenterJay K Wasman - Case Western Reserve UniversityJingqin R Luo - Washington University in St. LouisDavid J Adelstein - Cleveland ClinicShlomo A Koyfman - Cleveland ClinicJames S Lewis Jr - Vanderbilt University Medical CenterAnant Madabhushi - The Wallace H. Coulter Department of Biomedical Engineering
- Resource Type
- Journal article
- Publication Details
- Cancer, Vol.128(21), pp.3831-3842
- DOI
- 10.1002/cncr.34446
- PMID
- 36066461
- PMCID
- PMC9782693
- ISSN
- 0008-543X
- eISSN
- 1097-0142
- Grant note
- U01 CA248226 / NCI NIH HHS R43 EB028736 / NIBIB NIH HHS R01 CA257612 / NCI NIH HHS CX001953 / VA C06 RR012463 / NCRR NIH HHS R01 CA268207 / NCI NIH HHS U01 CA239055 / NCI NIH HHS U01 CA269181 / NCI NIH HHS K07 CA218247 / NCI NIH HHS U54 CA254566 / NCI NIH HHS I01 BX004121 / BLRD VA R01 CA208236 / NCI NIH HHS R01 CA216579 / NCI NIH HHS T32 DC000028 / NIDCD NIH HHS IK2 CX001953 / CSRD VA R01 CA220581 / NCI NIH HHS R01 HL158071 / NHLBI NIH HHS R01 CA268287 / NCI NIH HHS R01 CA249992 / NCI NIH HHS R01 HL151277 / NHLBI NIH HHS U24 CA199374 / NCI NIH HHS P30 CA091842 / NCI NIH HHS R01 CA202752 / NCI NIH HHS
- Language
- English
- Date published
- 11/01/2022
- Academic Unit
- Radiation Oncology
- Record Identifier
- 9984696711302771
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