Image-based biomechanics of collagen-based tissue equivalents

Edward A Sander; Triantafyllos Stylianopoulos; Robert T Tranquillo; Victor H Barocas

doi:10.1109/MEMB.2009.932486

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Journal article

Image-based biomechanics of collagen-based tissue equivalents

Edward A Sander, Triantafyllos Stylianopoulos, Robert T Tranquillo and Victor H Barocas

IEEE engineering in medicine and biology magazine, Vol.28(3), pp.10-18

05/2009

DOI: 10.1109/MEMB.2009.932486

PMCID: PMC2762792

PMID: 19457729

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Abstract

In this study, we compared experimentally measured fiber network kinematics and the macroscopic mechanical response from cell-compacted, cross-shaped collagen gels (cruciforms), with the predictions from our multiscale modeling technique. The macroscopic finite element model matched the physical dimensions and boundary conditions of the experimental cruciform to be modeled. Different microscale network models were constructed for each finite element that matched fiber microstructure described by maps of the local direction and strength of alignment obtained from polarimetric alignment imaging. The outputs of the multiscale model included the macroscopic load-deformation response and the microscopic (fiber) kinematics.

Biomedical Engineering

Finite Element Analysis

Biomechanical Phenomena

Animals

Gels

Cattle

Models, Biological

Biocompatible Materials - chemistry

Stress, Mechanical

Fibrillar Collagens - chemistry

In Vitro Techniques

Fibrillar Collagens - physiology

Details

Title: Subtitle: Image-based biomechanics of collagen-based tissue equivalents
Creators: Edward A Sander - Department of Biomedical Engineering, University of Minnesota, Minneapolis, USA
Triantafyllos Stylianopoulos
Robert T Tranquillo
Victor H Barocas
Resource Type: Journal article
Publication Details: IEEE engineering in medicine and biology magazine, Vol.28(3), pp.10-18
DOI: 10.1109/MEMB.2009.932486
PMID: 19457729
PMCID: PMC2762792
NLM abbreviation: IEEE Eng Med Biol Mag
ISSN: 0739-5175
eISSN: 1937-4186
Publisher: United States
Grant note: R01 EB005813-01 / NIBIB NIH HHS F32 EB007433-01A1 / NIBIB NIH HHS 1 F32 EB007433-01A1 / NIBIB NIH HHS R01 EB005813 / NIBIB NIH HHS 1 R01 EB005813-01 / NIBIB NIH HHS F32 EB007433 / NIBIB NIH HHS
Language: English
Date published: 05/2009
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Orthopedics and Rehabilitation; Craniofacial Anomalies Research Center; Chemical and Biochemical Engineering
Record Identifier: 9984064564102771

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