Journal article
Image-based modeling of lung structure and function
Journal of magnetic resonance imaging, Vol.32(6), pp.1421-1431
12/2010
DOI: 10.1002/jmri.22382
PMCID: PMC3058528
PMID: 21105146
Abstract
Current state-of-the-art in image-based modeling allows derivation of patient-specific models of the lung, lobes, airways, and pulmonary vascular trees. The application of traditional engineering analyses of fluid and structural mechanics to image-based subject-specific models has the potential to provide new insight into structure-function relationships in the individual via functional interpretation that complements imaging and experimental studies. Three major issues that are encountered in studies of air flow through the bronchial airways are the representation of airway geometry, the imposition of physiological boundary conditions, and the treatment of turbulence. Here we review some efforts to resolve each of these issues, with particular focus on image-based models that have been developed to simulate air flow from the mouth to the terminal bronchiole, and subjected to physiologically meaningful boundary conditions via image registration and soft tissue mechanics models.
Details
- Title: Subtitle
- Image-based modeling of lung structure and function
- Creators
- Merryn H Tawhai - Auckland Bioengineering Institute, The University of Auckland, Auckland, New ZealandChing-Long Lin - Department of Mechanical and Industrial Engineering, and IIHR-Hydroscience & Engineering, The University of Iowa, Iowa City, Iowa 52242
- Resource Type
- Journal article
- Publication Details
- Journal of magnetic resonance imaging, Vol.32(6), pp.1421-1431
- DOI
- 10.1002/jmri.22382
- PMID
- 21105146
- PMCID
- PMC3058528
- ISSN
- 1053-1807
- eISSN
- 1522-2586
- Language
- English
- Date published
- 12/2010
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Mechanical Engineering
- Record Identifier
- 9984064241002771
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