Imaging Based Assessment of Lung Function in a Population Cooking Indoors with Biomass Fuel - A Pilot Study

Abhilash S Kizhakke Puliyakote; Emma M Stapleton; Kumar Durairaj; Kesavan Karuppusamy; Geetha B Kathiresan; Kumaran Shanmugam; Sirajunissa Abdul Rahim; Suresh Navaneethakrishnan; Monalisa Bilas; Rui Huang; Nervana Metwali; Matthew Jeronimo; Kung-Sik Chan; Junfeng Guo; Prashant Nagpal; Thomas M Peters; Peter S Thorne; Alejandro P Comellas; Eric A Hoffman

doi:10.1152/japplphysiol.00286.2022

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Imaging Based Assessment of Lung Function in a Population Cooking Indoors with Biomass Fuel - A Pilot Study

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Imaging Based Assessment of Lung Function in a Population Cooking Indoors with Biomass Fuel - A Pilot Study

Abhilash S Kizhakke Puliyakote, Emma M Stapleton, Kumar Durairaj, Kesavan Karuppusamy, Geetha B Kathiresan, Kumaran Shanmugam, Sirajunissa Abdul Rahim, Suresh Navaneethakrishnan, Monalisa Bilas, Rui Huang, …

Journal of applied physiology (1985), Vol.134(3), pp.710-721

03/14/2023

DOI: 10.1152/japplphysiol.00286.2022

PMCID: PMC10027118

PMID: 36759166

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027118View

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Abstract

Biomass fuels (wood) are commonly used indoors in under-ventilated environments for cooking in the developing world, but the impact on lung physiology is poorly understood. Quantitative computed tomography (qCT) can provide sensitive metrics to compare the lungs of women cooking with wood vs. liquified petroleum gas (LPG). We prospectively assessed (qCT and spirometry) 23 primary female cooks (18 biomass, 5 LPG) with no history of cardiopulmonary disease in Thanjavur, India. CT was obtained at coached total lung capacity (TLC) and residual volume (RV). qCT assessment included texture-derived ground-glass-opacity (GGO: Adaptive Multiple Feature Method (AMFM)), air-trapping (expiratory voxels ≤-856HU) and image registration-based assessment (Disease Probability Measure (DPM)) of emphysema, functional small airways disease (%AirTrap ) and regional lung mechanics. Additionally, within-kitchen exposure assessments included particulate matter <2.5μm(PM ), black carbon, β-(1,3)-D-glucan (surrogate for fungi), and endotoxin. Air-trapping went undetected at RV via the threshold-based measure (voxels≤-856HU), possibly due to density shifts in the presence of inflammation. However, DPM, utilizing image-matching, demonstrated significant air-trapping in biomass vs. LPG cooks (p=0.049). A subset of biomass cooks (6/18), identified using k-means clustering, had markedly altered DPM-metrics: greater air-trapping (p<0.001); lower TLC-RV volume change (p<0.001), a lower mean anisotropic deformation index (ADI) (p<0.001) and elevated % GGO (p<0.02). Across all subjects, a texture measure of bronchovascular bundles was correlated to the log-transformed β-(1,3)-D-glucan concentration (p=0.026, R=0.46), and black carbon (p=0.04, R=0.44). This pilot study identified environmental links with qCT-based lung pathologies and a cluster of biomass cooks (33%) with significant small airways disease.

hut lung

image registration

environmental exposure

quantitative computed tomography

functional small airways disease

Details

Title: Subtitle: Imaging Based Assessment of Lung Function in a Population Cooking Indoors with Biomass Fuel - A Pilot Study
Creators: Abhilash S Kizhakke Puliyakote - Biomedical Engineering, University of Iowa, Iowa City, IA, United States
Emma M Stapleton - Internal Medicine, University of Iowa, Iowa City, IA, United States
Kumar Durairaj - Physics, Periyar Maniammai Institute of Science and Technology, Thanjavur, Tamil Nadu, India
Kesavan Karuppusamy - Physics, Periyar Maniammai Institute of Science and Technology, Thanjavur, Tamil Nadu, India
Geetha B Kathiresan - Electronics and Communication Engineering, Periyar Maniammai Institute of Science and Technology, Thanjavur, Tamil Nadu, India
Kumaran Shanmugam - Biotechnology, Periyar Maniammai Institute of Science and Technology, Thanjavur, Tamil Nadu, India
Sirajunissa Abdul Rahim - Department of Chemistry, K. Ramakrishnan College of Engineering, Trichy, Tamil Nadu, India
Suresh Navaneethakrishnan - Suresh Scan Centre, Thanjavur, Tamil Nadu, India
Monalisa Bilas - Department of Radiology, University of Iowa, Iowa City, IA, United States
Rui Huang - Nanjing University
Nervana Metwali - University of Iowa
Matthew Jeronimo - University of British Columbia
Kung-Sik Chan - Statistics and Actuarial Science, University of Iowa, Iowa City, IA, United States
Junfeng Guo - University of Iowa
Prashant Nagpal - University of Wisconsin–Madison
Thomas M Peters - University of Iowa
Peter S Thorne - University of Iowa
Alejandro P Comellas - Internal Medicine, University of Iowa, Iowa City, IA, United States
Eric A Hoffman - University of Iowa
Resource Type: Journal article
Publication Details: Journal of applied physiology (1985), Vol.134(3), pp.710-721
DOI: 10.1152/japplphysiol.00286.2022
PMID: 36759166
PMCID: PMC10027118
eISSN: 1522-1601
Grant note: R01HL126838 / HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL112986 / HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL130883 / HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL091842-11 / HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) Clifford V. Bowers Emphysema Research Fund 5P30 ES005605 / HHS | NIH | National Institute of Environmental Health Sciences (NIEHS)
Language: English
Electronic publication date: 02/09/2023
Date published: 03/14/2023
Academic Unit: Statistics and Actuarial Science; Roy J. Carver Department of Biomedical Engineering; Radiology; Pulmonary, Critical Care, and Occupational Medicine; Civil and Environmental Engineering; Occupational and Environmental Health; ICTS; Internal Medicine
Record Identifier: 9984366358802771

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