Journal article
Imaging Features of Alveolar Soft Part Sarcoma: A Report from Children's Oncology Group Study ARST0332
American journal of roentgenology (1976), Vol.203(6), pp.1345-1352
12/2014
DOI: 10.2214/AJR.14.12462
PMCID: PMC4438280
PMID: 25415714
Abstract
Objective: There are few studies in the literature regarding the imaging features of alveolar soft-part sarcoma (ASPS). We performed a comprehensive assessment of the imaging characteristics of this rare tumor to determine whether there are features that suggest the diagnosis.
Materials and methods: Twenty-two subjects with ASPS underwent pretherapy imaging as part of enrollment in Children's Oncology Group protocol ARST0332 for the treatment of nonrhabdomyosarcoma soft-tissue sarcomas: 16 patients underwent MRI; three, CT; and three, both MRI and CT. Two radiologists retrospectively reviewed the imaging studies by consensus and recorded tumor location, size, contour, internal architecture, signal characteristics, presence of flow voids, and enhancement patterns.
Results: The 12 females and 10 males in the study group ranged in age from 8 to 23 years 7 months (mean, 15 years 8 months). The most common anatomic site was the lower extremity (12/22, 55%) followed by the upper extremity (4/22, 18%). The maximal tumor diameter ranged from 2.3 to 20.0 cm (median, 5.9 cm). All tumors imaged with MRI had flow voids (19/19, 100%), and 19 (19/22, 86%) had large peripheral vessels, lobulated margins, and nodular internal architecture. Unenhanced T1-weighted MRI was available for 18 tumors: 14 (14/18, 78%) appeared slightly hyperintense to muscle. Of the 16 tumors imaged with contrast material, 11 (11/16, 69%) showed intense enhancement and five (5/16, 31%), moderate enhancement. Six tumors (6/16, 38%) had a thick enhancing peripheral rim with a nonenhancing center consistent with necrosis.
Conclusion: The imaging features of ASPS include flow voids, large peripheral vessels, internal nodularity, and lobulated margins. Contrast administration produces intense to moderate enhancement, sometimes with a thick enhancing peripheral rim around central necrosis. Extremity tumors with these imaging features in a child or young adult should suggest the diagnosis of ASPS.
Details
- Title: Subtitle
- Imaging Features of Alveolar Soft Part Sarcoma: A Report from Children's Oncology Group Study ARST0332
- Creators
- M. Beth McCarville - Department of Radiological Sciences, St. Jude Children's Research Hospital, Memphis, TNSofia Muzzafar - Department of Radiological Sciences, St. Jude Children's Research Hospital, Memphis, TNSimon C Kao - Department of Radiology, the University of Iowa Hospitals and Clinics, Iowa City, IACheryl Coffin - Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TNDavid M Parham - Department of Pathology and Laboratory Medicine, Children's Hospital of Los Angeles and University of Southern California, Keck School of Medicine, Los Angeles, CAJames Anderson - Department of Biostatistics, University of Nebraska Medical Center, Omaha, NESheri L Spunt - Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA
- Resource Type
- Journal article
- Publication Details
- American journal of roentgenology (1976), Vol.203(6), pp.1345-1352
- DOI
- 10.2214/AJR.14.12462
- PMID
- 25415714
- PMCID
- PMC4438280
- NLM abbreviation
- AJR Am J Roentgenol
- ISSN
- 0361-803X
- eISSN
- 1546-3141
- Language
- English
- Date published
- 12/2014
- Academic Unit
- Radiology; Stead Family Department of Pediatrics
- Record Identifier
- 9984051575902771
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