Journal article
Imaging and dosimetric characteristics of (67) Cu
Physics in medicine & biology, Vol.66(3), 035002
02/07/2021
DOI: 10.1088/1361-6560/abca52
PMID: 33496267
Abstract
In recent years the use of beta-emitting radiopharmaceuticals for cancer therapy has expanded rapidly following development of therapeutics for neuroendocrine tumors, prostate cancer, and other oncologic malignancies. One emerging beta-emitting radioisotope of interest for therapy is Cu-67 (t(1/2): 2.6 d) due to its chemical equivalency with the widely-established positron-emitting isotope Cu-64 (t(1/2): 12.7 h). In this work we evaluate both the imaging and dosimetric characteristics of Cu-67, as well as producing the first report of SPECT/CT imaging using Cu-67. To this end, Cu-67 was produced by photon-induced reactions on isotopically-enriched Zn-68 at the Low-Energy Accelerator Facility (LEAF) of Argonne National Laboratory, followed by bulk separation of metallic Zn-68 by sublimation and radiochemical purification by column chromatography. Gamma spectrometry was performed by efficiency-calibrated high-purity germanium (HPGe) analysis to verify absolute activity calibration and establish radionuclidic purity. Absolute activity measurements corroborated manufacturer-recommended dose-calibrator settings and no radionuclidic impurities were observed. Using the Clinical Trials Network anthropomorphic chest phantom, SPECT/CT images were acquired. Medium energy (ME) SPECT collimation was found to provide the best image quality from the primary 185 keV gamma emission of Cu-67. Reconstructed images of Cu-67 were similar in quality to images acquired using Lu-177. Recovery coefficients were calculated and compared against quantitative images of Tc-99m, Lu-177, and Cu-64 within the same anthropomorphic chest phantom. Production and clinical imaging of Cu-67 appears feasible, and future studies investigating the therapeutic efficacy of Cu-67-based radiopharmaceuticals are warranted.
Details
- Title: Subtitle
- Imaging and dosimetric characteristics of (67) Cu
- Creators
- Michael J. Merrick - University of IowaDavid A. Rotsch - Argonne National LaboratoryAshok Tiwari - University of IowaJerry Nolen - Argonne National LaboratoryThomas Brossard - Argonne National LaboratoryJeongseog Song - Argonne National LaboratoryThaddeus J. Wadas - University of IowaJohn J. Sunderland - University of IowaStephen A. Graves - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Physics in medicine & biology, Vol.66(3), 035002
- DOI
- 10.1088/1361-6560/abca52
- PMID
- 33496267
- NLM abbreviation
- Phys Med Biol
- ISSN
- 0031-9155
- eISSN
- 1361-6560
- Publisher
- Iop Publishing Ltd
- Number of pages
- 11
- Grant note
- U.S. Department of Energy Isotope Program
- Language
- English
- Date published
- 02/07/2021
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Physics and Astronomy; Radiation Oncology
- Record Identifier
- 9984313071602771
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