Imaging aspirin effect on macrophages in the wall of human cerebral aneurysms using ferumoxytol-enhanced MRI: preliminary results

David M Hasan; Nohra Chalouhi; Pascal Jabbour; Vincent A Magnotta; David K Kung; William L Young

doi:10.1016/j.neurad.2012.09.002

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Imaging aspirin effect on macrophages in the wall of human cerebral aneurysms using ferumoxytol-enhanced MRI: preliminary results

Journal article

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Peer reviewed

Imaging aspirin effect on macrophages in the wall of human cerebral aneurysms using ferumoxytol-enhanced MRI: preliminary results

David M Hasan, Nohra Chalouhi, Pascal Jabbour, Vincent A Magnotta, David K Kung and William L Young

Journal of neuroradiology, Vol.40(3), pp.187-191

07/2013

DOI: 10.1016/j.neurad.2012.09.002

PMCID: PMC7853080

PMID: 23428244

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https://www.ncbi.nlm.nih.gov/pmc/articles/7853080View

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Abstract

Daily intake of aspirin was shown to decrease human cerebral aneurysm rupture by 60%. The feasibility of imaging macrophages in human cerebral aneurysm walls using ferumoxytol-enhanced MRI has been demonstrated. The goal of the present study is to image aspirin effect on macrophages in the wall of human cerebral aneurysm using ferumoxytol-enhanced MRI. Five patients with known intracranial aneurysms underwent baseline imaging using T2(*) gradient-echo and T1 MRI sequences using ferumoxytol-enhanced MRI 72-hour post-ferumoxytol infusion. Patients then received 81 mg aspirin per os daily. After 3 months, imaging studies were repeated and analyzed by co-registration using a histogram and subtraction of follow-up images from baseline. In all five patients, after 3 months of treatment with aspirin, the signal intensity corresponding to the uptake of ferumoxytol by macrophages in the aneurysm wall was less intense than in the baseline images. This was confirmed by co-registration of images using histogram and subtraction of follow-up images from baseline. These preliminary results suggest the feasibility of imaging aspirin effect on macrophages localized in the wall of human cerebral aneurysm using ferumoxytol-enhanced MRI. The findings provide radiographic evidence of decreased inflammation in human cerebral aneurysms with daily intake of aspirin using macrophages as a surrogate marker for inflammation.

Macrophages - pathology

Humans

Middle Aged

Aneurysm, Ruptured - prevention & control

Fibrinolytic Agents - pharmacology

Magnetic Resonance Imaging

Ferrosoferric Oxide

Female

Macrophages - drug effects

Aged

Aneurysm, Ruptured - pathology

Aspirin - pharmacology

Intracranial Aneurysm - pathology

Details

Title: Subtitle: Imaging aspirin effect on macrophages in the wall of human cerebral aneurysms using ferumoxytol-enhanced MRI: preliminary results
Creators: David M Hasan - Department of Neurosurgery, Carver College of Medicine, University of Iowa, Iowa City, IA, USA. david-hasan@uiowa.edu
Nohra Chalouhi
Pascal Jabbour
Vincent A Magnotta
David K Kung
William L Young
Resource Type: Journal article
Publication Details: Journal of neuroradiology, Vol.40(3), pp.187-191
DOI: 10.1016/j.neurad.2012.09.002
PMID: 23428244
PMCID: PMC7853080
NLM abbreviation: J Neuroradiol
ISSN: 0150-9861
eISSN: 1773-0406
Publisher: France
Grant note: R03NS07922 / NINDS NIH HHS R03 NS079227 / NINDS NIH HHS
Language: English
Date published: 07/2013
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Psychiatry; Iowa Neuroscience Institute; Neurosurgery; Otolaryngology
Record Identifier: 9984040274802771

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