Journal article
Imaging correlates for the 2016 update on WHO classification of grade II/III gliomas: implications for IDH, 1p/19q and ATRX status
Journal of neuro-oncology, Vol.135(3), pp.601-609
12/2017
DOI: 10.1007/s11060-017-2613-7
PMCID: PMC5700844
PMID: 28871469
Abstract
The 2016 World Health Organization Classification of Tumors of the Central Nervous System incorporates the use of molecular information into the classification of brain tumors, including grade II and III gliomas, providing new prognostic information that cannot be delineated based on histopathology alone. We hypothesized that these genomic subgroups may also have distinct imaging features. A retrospective single institution study was performed on 40 patients with pathologically proven infiltrating WHO grade II/III gliomas with a pre-treatment MRI and molecular data on IDH, chromosomes 1p/19q and ATRX status. Two blinded Neuroradiologists qualitatively assessed MR features. The relationship between each parameter and molecular subgroup (IDH-wildtype; IDH-mutant-1p/19q codeleted-ATRX intact; IDH-mutant-1p/19q intact-ATRX loss) was evaluated with Fisher's exact test. Progression free survival (PFS) was also analyzed. A border that could not be defined on FLAIR was most characteristic of IDH-wildtype tumors, whereas IDH-mutant tumors demonstrated either well-defined or slightly ill-defined borders (p = 0.019). Degree of contrast enhancement and presence of restricted diffusion did not distinguish molecular subgroups. Frontal lobe predominance was associated with IDH-mutant tumors (p = 0.006). The IDH-wildtype subgroup had significantly shorter PFS than the IDH-mutant groups (p < 0.001). No differences in PFS were present when separating by tumor grade. FLAIR border patterns and tumor location were associated with distinct molecular subgroups of grade II/III gliomas. These imaging features may provide fundamental prognostic and predictive information at time of initial diagnostic imaging.
Details
- Title: Subtitle
- Imaging correlates for the 2016 update on WHO classification of grade II/III gliomas: implications for IDH, 1p/19q and ATRX status
- Creators
- Rachel L Delfanti - Center for Multimodal Imaging and Genetics, University of California, San Diego, La Jolla, CA, 92037, USA. rdelfanti@ucsd.eduDavid E Piccioni - Department of Neurosciences, University of California, San Diego, La Jolla, CA, 92037, USAJason Handwerker - Department of Radiology, University of California, San Diego, 200 West Arbor Drive, La Jolla, CA, 92037, USANaeim Bahrami - Center for Multimodal Imaging and Genetics, University of California, San Diego, La Jolla, CA, 92037, USAAnithaPriya Krishnan - Center for Multimodal Imaging and Genetics, University of California, San Diego, La Jolla, CA, 92037, USARoshan Karunamuni - Department of Radiation Medicine, University of California, San Diego, La Jolla, CA, 92037, USAJona A Hattangadi-Gluth - Department of Radiation Medicine, University of California, San Diego, La Jolla, CA, 92037, USATyler M Seibert - Department of Radiation Medicine, University of California, San Diego, La Jolla, CA, 92037, USAAshwin Srikant - Center for Multimodal Imaging and Genetics, University of California, San Diego, La Jolla, CA, 92037, USAKarra A Jones - Department of Pathology, University of Iowa Hospitals & Clinics, Iowa City, IA, 52242, USAVivian S Snyder - Department of Pathology, University of California, San Diego, La Jolla, CA, 92093, USAAnders M Dale - Center for Multimodal Imaging and Genetics, University of California, San Diego, La Jolla, CA, 92037, USANathan S White - Center for Multimodal Imaging and Genetics, University of California, San Diego, La Jolla, CA, 92037, USACarrie R McDonald - Department of Psychiatry, University of California, San Diego, La Jolla, CA, 92037, USANikdokht Farid - Center for Multimodal Imaging and Genetics, University of California, San Diego, La Jolla, CA, 92037, USA
- Resource Type
- Journal article
- Publication Details
- Journal of neuro-oncology, Vol.135(3), pp.601-609
- Publisher
- United States
- DOI
- 10.1007/s11060-017-2613-7
- PMID
- 28871469
- PMCID
- PMC5700844
- ISSN
- 0167-594X
- eISSN
- 1573-7373
- Grant note
- TPR 15-229 / HSRD VA 1430082 / National Science Foundation Grant R01NS065838 / National Institutes of Health R01 EB000790 / NIBIB NIH HHS KL2 TR000099 / NCATS NIH HHS EB00790-06 / National Institutes of Health (US) UL1TR000100 / National Institutes of Health RC2 DA029475 / NIDA NIH HHS ACS-IRG 70-002 / American Cancer Society P30 CA023100 / NCI NIH HHS P30CA023100 / National Cancer Institute Cancer Center Specialized Grant UL1 TR000100 / NCATS NIH HHS RSG-15-229-01-CCE / American Cancer Society R01 NS065838 / NINDS NIH HHS KL2TR00099 / National Institutes of Health RC2DA29475 / National Institutes of Health
- Language
- English
- Date published
- 12/2017
- Academic Unit
- Pathology
- Record Identifier
- 9984047898702771
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