Journal article
Imaging findings of familial Mediterranean fever
Clinical imaging, Vol.30(3), pp.153-159
05/01/2006
DOI: 10.1016/j.clinimag.2005.07.002
PMID: 16632148
Abstract
Purpose
The aim of this study was to study the imaging findings of familial Mediterranean fever (FMF).
Materials and methods
We performed a retrospective review of the medical records and imaging studies of 38 patients with proven FMF, diagnosed between 1992 and 2002.
Results
The most common clinical manifestation was recurrent peritoneal attacks with abdominal pain (76.3%) and fever (42.1%). Abdominal imaging findings included ileus (n=12), splenomegaly (n=5), hepatomegaly (n=2), ascitis (n=2), focal peritonitis (n=2), mesenteric streaking (n=1), and enlarged mesenteric lymph node (n=1). One patient developed fatal peritoneal mesothelioma, and 13.1% of the patients developed amyloidosis with sonographic findings of renal parenchymal disease or cardiomyopathy. Arthritis was second in frequency, occurring in 34.2% of patients; radiographs were normal (n=4) or showed joint effusion and periarticular soft tissue swelling (n=4) due to synovitis. One patient developed seronegative destructive arthropathy. Skin lesions were noted in 23.6% of patients. Pleuritis was encountered in 13.1% and pericarditis in 5.2%. Polyarteritis nodosa (PAN) was present in two patients, multiple sclerosis in one, and autoimmune hemolytic anemia in one patient.
Conclusion
FMF predominantly involves abdominal viscera but can affect other organs. The majority of patients have nonspecific imaging findings, and the radiologic diagnosis is rarely considered. Amyloidosis, mesothelioma, and destructive arthropathy are potential serious complications of FMF. PAN, multiple sclerosis, and autoimmune hemolytic anemia are probably rare associations or rather than coincident with FMF.
Details
- Title: Subtitle
- Imaging findings of familial Mediterranean fever
- Creators
- Gisele E Ishak - American University of BeirutNabil J Khoury - American University of BeirutGhina A Birjawi - American University of BeirutYoussef R EL-ZEIN - American University of BeirutLena N Naffaa - American University of BeirutMaurice C Haddad - American University of Beirut
- Resource Type
- Journal article
- Publication Details
- Clinical imaging, Vol.30(3), pp.153-159
- Publisher
- Elsevier
- DOI
- 10.1016/j.clinimag.2005.07.002
- PMID
- 16632148
- ISSN
- 0899-7071
- eISSN
- 1873-4499
- Language
- English
- Date published
- 05/01/2006
- Academic Unit
- Radiology
- Record Identifier
- 9984697639402771
Metrics
2 Record Views