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Imaging microglia in live brain slices and slice cultures
Journal article

Imaging microglia in live brain slices and slice cultures

Dana Kurpius and Michael E Dailey
CSH protocols, Vol.2007, pp.1142-1148
10/01/2007
DOI: 10.1101/pdb.prot4852
PMID: 21356950

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Abstract

INTRODUCTION This protocol describes methods for fluorescence labeling and time-lapse confocal imaging of microglia in acutely prepared tissue slices from developing and adult animals, and to slice cultures derived from early post-natal day 7 (<PND7) animals. The techniques permit real-time analyses of microglial structure and dynamic remodeling in live rodent brain tissues.

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