Journal article
Imaging morphogenesis of Candida albicans during infection in a live animal
Journal of biomedical optics, Vol.15(1), pp.010504-010504
2010
DOI: 10.1117/1.3290243
PMCID: PMC2816988
PMID: 20210419
Abstract
Candida albicans
is an opportunistic human fungal pathogen that requires an intact host immune response to prevent disease. Thus, studying host-pathogen interactions is critical to understanding and preventing this disease. We report a new model infection system in which ongoing
C. albicans
infections can be imaged at high spatial resolution in the ears of living mice. Intradermal inoculation into mouse ears with a
C. albicans
strain expressing green fluorescent protein results in systemic
C. albicans
infection that can be imaged
in vivo
using confocal microscopy. We observed filamentous growth of the organism
in vivo
as well as formation of microabscesses. This model system will allow us to gain significant new information about
C. albicans
pathogenesis through studies of host-
C. albicans
interactions in the native environment.
Details
- Title: Subtitle
- Imaging morphogenesis of Candida albicans during infection in a live animal
- Creators
- Soumya Mitra - University of Rochester Medical Center, Department of Imaging Sciences, 601 Elmwood Avenue, Box 648, Rochester, New York 1462Kristy Dolan - University of Rochester Medical Center, Department of Pediatrics, 601 Elmwood Avenue, Box 690, Rochester, New York 14642Thomas H Foster - University of Rochester Medical Center, Department of Imaging Sciences, 601 Elmwood Avenue, Box 648, Rochester, New York 1462Melanie Wellington - University of Rochester Medical Center, Department of Pediatrics, 601 Elmwood Avenue, Box 690, Rochester, New York 14642
- Resource Type
- Journal article
- Publication Details
- Journal of biomedical optics, Vol.15(1), pp.010504-010504
- Publisher
- Society of Photo-Optical Instrumentation Engineers
- DOI
- 10.1117/1.3290243
- PMID
- 20210419
- PMCID
- PMC2816988
- ISSN
- 1083-3668
- eISSN
- 1560-2281
- Language
- English
- Date published
- 2010
- Academic Unit
- Stead Family Department of Pediatrics; Infectious Disease (Pediatrics)
- Record Identifier
- 9984093335802771
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