Journal article
Imaging of Lung Function Using Hyperpolarized Helium-3 Magnetic Resonance Imaging: Review of Current and Emerging Translational Methods and Applications
Journal of magnetic resonance imaging, Vol.32(6), pp.1398-1408
12/01/2010
DOI: 10.1002/jmri.22375
PMCID: PMC3058806
PMID: 21105144
Abstract
During the past several years there has been extensive development and application of hyperpolarized helium-3 (HP He-3) magnetic resonance imaging (MRI) in clinical respiratory indications such as asthma chronic obstructive pulmonary disease cystic fibrosis radiation-induced lung injury and transplantation This review focuses on the state-of-the-art of HP 3He MRI and its application to clinical pulmonary research This is not an overview of the physics of the method as this topic has been covered previously We focus here on the potential of this imaging method and its challenges in demonstrating new types of information that has the potential to influence clinical research and decision making in pulmonary medicine Particular attention is given to functional imaging approaches related to ventilation and diffusion-weighted imaging with applications in chronic obstructive pulmonary disease cystic fibrosis, asthma and radiation-induced lung injury The strengths and challenges of the application of 3He MRI in these indications are discussed along with a comparison to established and emerging imaging techniques
Details
- Title: Subtitle
- Imaging of Lung Function Using Hyperpolarized Helium-3 Magnetic Resonance Imaging: Review of Current and Emerging Translational Methods and Applications
- Creators
- Sean Fain - University of Wisconsin–MadisonMark L. Schiebler - University of Wisconsin–MadisonDavid G. McCormack - Western UniversityGrace Parraga - Western University
- Resource Type
- Journal article
- Publication Details
- Journal of magnetic resonance imaging, Vol.32(6), pp.1398-1408
- Publisher
- Wiley
- DOI
- 10.1002/jmri.22375
- PMID
- 21105144
- PMCID
- PMC3058806
- ISSN
- 1053-1807
- eISSN
- 1522-2586
- Number of pages
- 11
- Grant note
- Canadian Institutes of Health Research (CIHR) Canadian Lung Association (Ontario Thoracic Society); Canadian Institutes of Health Research (CIHR) R01HL069116 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) NHLBI; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) Academic Medical Organization of Southwestern Ontario R01DK073680 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) Canadian Institutes of Health Research Canadian Thoracic Society; Canadian Institutes of Health Research (CIHR) Hartwell Foundation Ontario Research Fund National Institutes of Health/National Heart Lung and Blood Institute (NHLBI); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Language
- English
- Date published
- 12/01/2010
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health and Human Physiology
- Record Identifier
- 9984275055902771
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