Imaging of chronic granulomatous disease in children

Geetika Khanna; Simon C Kao; Patricia Kirby; Yutaka Sato

doi:10.1148/rg.255055011

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Imaging of chronic granulomatous disease in children

Journal article

Open access

Peer reviewed

Imaging of chronic granulomatous disease in children

Geetika Khanna, Simon C Kao, Patricia Kirby and Yutaka Sato

Radiographics, Vol.25(5), pp.1183-1195

09/2005

DOI: 10.1148/rg.255055011

PMID: 16160105

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Abstract

Chronic granulomatous disease (CGD) is a rare immunodeficiency disorder. The inability of phagocytic cells to kill catalase-positive organisms, such as Staphylococcus and Aspergillus species, causes recurrent infections, persistent inflammation, and granuloma formation. The imaging findings in nine cases of CGD were studied. Recurrent pulmonary infection was the most common abnormality (seven cases). Its complications included pulmonary abscesses, bronchiectasis, mediastinal abscesses, osteomyelitis, sepsis, and brain abscesses. Suppurative cervical adenitis was the second most common abnormality (four cases) and was also the presenting abnormality in the youngest patient (aged 31 days). Abdominal manifestations included hepatosplenomegaly, recurrent hepatic and splenic abscesses, necrotic mesenteric adenopathy, and gastric outlet obstruction. Osteomyelitis occurred in two cases secondary to hematogenous spread or spread of contiguous infection from the lung. Persistent infections led to formation of chronic inflammatory masses and granulomas in five cases. With improvements in therapy, the prognosis of CGD patients has improved and the general consensus is that most patients will survive into adulthood. Hence, radiologists are more likely to encounter the complications of CGD and should familiarize themselves with the spectrum of imaging findings.

Granulomatous Disease, Chronic - diagnosis

Humans

Child, Preschool

Infant

Male

Granulomatous Disease, Chronic - complications

Granulomatous Disease, Chronic - etiology

Child

Granulomatous Disease, Chronic - epidemiology

Details

Title: Subtitle: Imaging of chronic granulomatous disease in children
Creators: Geetika Khanna - Department of Radiology, University of Iowa College of Medicine, Iowa City, USA. geetika-khanna@uiowa.edu
Simon C Kao
Patricia Kirby
Yutaka Sato
Resource Type: Journal article
Publication Details: Radiographics, Vol.25(5), pp.1183-1195
DOI: 10.1148/rg.255055011
PMID: 16160105
NLM abbreviation: Radiographics
ISSN: 1527-1323
eISSN: 1527-1323
Publisher: United States
Grant note: K30HL04117-01A1 / NHLBI NIH HHS R43DK061079-01 / NIDDK NIH HHS
Language: English
Date published: 09/2005
Academic Unit: Radiology; Stead Family Department of Pediatrics; Pathology
Record Identifier: 9984051529202771

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