Imaging of lung ventilation and respiratory dynamics in a single ventilation cycle using hyperpolarized He-3 MRI

James H. Holmes; Frank R. Korosec; Jiang Du; Rafael L. O'Halloran; Ronald L. Sorkness; Thomas M. Grist; Janet E. Kuhlman; Sean B. Fain

doi:10.1002/jmri.20965

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Imaging of lung ventilation and respiratory dynamics in a single ventilation cycle using hyperpolarized He-3 MRI

Journal article

Open access

Peer reviewed

Imaging of lung ventilation and respiratory dynamics in a single ventilation cycle using hyperpolarized He-3 MRI

James H. Holmes, Frank R. Korosec, Jiang Du, Rafael L. O'Halloran, Ronald L. Sorkness, Thomas M. Grist, Janet E. Kuhlman and Sean B. Fain

Journal of magnetic resonance imaging, Vol.26(3), pp.630-636

09/2007

DOI: 10.1002/jmri.20965

PMID: 17685417

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Abstract

Purpose: To image respiratory dynamics and three-dimensional (3D) ventilation during inhalation, breath-hold, and exhalation for evaluation of obstructive lung disease using a single dose of hyperpolarized (HP) He-3 during MRI. Materials and Methods: A single 2D-3D projections inside Z encoding (PRIZE)-2D acquisition was performed that consisted of a rapid 2D radial acquisition phase during inhalation of the HP He-3, a 3D acquisition phase during a breath-hold interval, and finally the same 2D radial acquisition during a forced exhalation maneuver followed by tidal breathing. The 3D PRIZE acquisition was comprised of radial sampling in the coronal plane and Fourier encoding in the patient's anterior-posterior direction. Nine patients with mild/moderate to severe asthma were studied (two individuals were studied twice) using this technique. Results: Breath-hold and dynamic imaging results showed physiological abnormalities and were compared with results from standard spirometry, body plethysmography, and computed tomography (CT). Dynamic images depicted regions of differential gas clearance and trapping observed during and alter forced exhalation that were corroborated as regions of air trapping on CT imaging. Conclusion: The 2D-3D PRIZE-2D acquisition allowed for 3D depiction of ventilation during a breath-hold, as well as detection of gas trapping. Imaging results were confirmed with spirometry, body plethysmography, and CT. © 2007 Wiley-Liss, Inc.

Asthma

gas trapping

hyperpolarized helium-3

lung

radial

ventilation

Details

Title: Subtitle: Imaging of lung ventilation and respiratory dynamics in a single ventilation cycle using hyperpolarized He-3 MRI
Creators: James H. Holmes - University of Wisconsin–Madison
Frank R. Korosec - University of Wisconsin–Madison
Jiang Du - University of California San Diego
Rafael L. O'Halloran - University of Wisconsin–Madison
Ronald L. Sorkness - University of Wisconsin–Madison
Thomas M. Grist - University of Wisconsin–Madison
Janet E. Kuhlman - University of Wisconsin–Madison
Sean B. Fain - University of Wisconsin–Madison
Resource Type: Journal article
Publication Details: Journal of magnetic resonance imaging, Vol.26(3), pp.630-636
DOI: 10.1002/jmri.20965
PMID: 17685417
NLM abbreviation: J Magn Reson Imaging
ISSN: 1053-1807
eISSN: 1522-2586
Publisher: Wiley Subscription Services, Inc., A Wiley Company
Number of pages: 7
Language: English
Date published: 09/2007
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health, Sport, and Human Physiology
Record Identifier: 9984274958902771

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