Journal article
Imaging of musculoskeletal manifestations in sickle cell disease patients
British journal of radiology, Vol.90(1073), pp.20160130-20160130
05/2017
DOI: 10.1259/bjr.20160130
PMCID: PMC5605094
PMID: 28281830
Abstract
Sickle cell disease (SCD) is a hereditary red cell disorder with clinical manifestations secondary to sickling or crescent-shaped distortion of the red blood cells. Major clinical manifestations of SCD include haemolytic anaemia and vaso-occlusive phenomena resulting in ischaemic tissue injury and organ damage. Chronic sequelae of the anaemia and vaso-occlusive processes involving the musculoskeletal system include complications related to extramedullary haematopoiesis, osteonecrosis, myonecrosis and osteomyelitis. Sickle cell bone disease is one of the commonest clinical presentations. Awareness and knowledge of the imaging features related to these complications are essential for early diagnosis and prompt management. In this article, the pathophysiology and key imaging findings related to these complications are reviewed.
Details
- Title: Subtitle
- Imaging of musculoskeletal manifestations in sickle cell disease patients
- Creators
- Vijaya Kosaraju - University Hospitals of ClevelandAlok Harwani - University Hospitals of ClevelandSasan Partovi - University Hospitals of ClevelandNicholas Bhojwani - University Hospitals of ClevelandVasant Garg - University Hospitals of ClevelandSabarish Ayyappan - University Hospitals of ClevelandChristos Kosmas - University Hospitals of ClevelandMark Robbin - University Hospitals of Cleveland
- Resource Type
- Journal article
- Publication Details
- British journal of radiology, Vol.90(1073), pp.20160130-20160130
- DOI
- 10.1259/bjr.20160130
- PMID
- 28281830
- PMCID
- PMC5605094
- ISSN
- 0007-1285
- eISSN
- 1748-880X
- Language
- English
- Date published
- 05/2017
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984359948302771
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