Journal article
Imaging synaptic zinc: promises and perils
Trends in neurosciences (Regular ed.), Vol.29(4), pp.200-206
04/2006
DOI: 10.1016/j.tins.2006.02.004
PMID: 16515810
Abstract
It is well established that some excitatory nerve terminals have high concentrations of Zn(2+) in their synaptic vesicles. For some time, it has been believed that synaptic Zn(2+) is released during neurotransmission and acts as a neuromodulator. Fluorescent Zn(2+) indicators that do not penetrate membranes offer the prospect of rendering the release of Zn(2+) visible. Here, I take a critical look at fluorimetric imaging experiments devised to determine whether Zn(2+) is released and show that they are particularly susceptible to artifacts. Moreover, I will argue that recent experiments suggest that, rather than being released, Zn(2+) is presented to the extracellular space firmly coordinated to presynaptic macromolecules.
Details
- Title: Subtitle
- Imaging synaptic zinc: promises and perils
- Creators
- Alan R Kay - Department of Biological Sciences, 336 BB, University of Iowa, Iowa City, IA 52242, USA. alan-kay@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Trends in neurosciences (Regular ed.), Vol.29(4), pp.200-206
- Publisher
- England
- DOI
- 10.1016/j.tins.2006.02.004
- PMID
- 16515810
- ISSN
- 0166-2236
- eISSN
- 1878-108X
- Language
- English
- Date published
- 04/2006
- Academic Unit
- Iowa Neuroscience Institute; Biology
- Record Identifier
- 9983991962102771
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