Imaging the Microvasculature of Choroidal Melanomas With Confocal Indocyanine Green Scanning Laser Ophthalmoscopy

Arthur J Mueller; Dirk-Uwe Bartsch; Robert Folberg; Mary G Mehaffey; H. Culver Boldt; Margaret Meyer; Lynn M Gardner; Michael H Goldbaum; Jacob Pe'er; William R Freeman

doi:10.1001/archopht.116.1.31

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Imaging the Microvasculature of Choroidal Melanomas With Confocal Indocyanine Green Scanning Laser Ophthalmoscopy

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Imaging the Microvasculature of Choroidal Melanomas With Confocal Indocyanine Green Scanning Laser Ophthalmoscopy

Arthur J Mueller, Dirk-Uwe Bartsch, Robert Folberg, Mary G Mehaffey, H. Culver Boldt, Margaret Meyer, Lynn M Gardner, Michael H Goldbaum, Jacob Pe'er and William R Freeman

Archives of ophthalmology (1960), Vol.116(1), pp.31-39

01/01/1998

DOI: 10.1001/archopht.116.1.31

PMID: 9445206

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Abstract

OBJECTIVE To image the microvasculature of choroidal melanoma with a new confocal scanning laser ophthalmoscope. METHODS Eighteen consecutive patients, each with a unilateral choroidal melanoma, were examined prospectively. Indocyanine green angiography was performed with a new confocal scanning laser ophthalmoscope that enabled serial optical sectioning through the tumor. Two additional patients were studied with indocyanine green angiography and confocal scanning laser ophthalmoscopy just before enucleation for posterior choroidal melanomas. The histologic identification of microvasculature patterns was compared with the angiograms for these patients. RESULTS In the series of 18 patients, 16 (89%) indocyanine green angiograms with optical sectioning revealed tubular structures within the melanoma that were identified as tumor vessels based on their angiographic appearance. The microvasculature patterns identified by indocyanine green angiography correlated well with the histologic appearance of these microvasculature patterns in both patients for whom histologic verification was available. CONCLUSIONS This preliminary study suggests that indocyanine green angiography with confocal scanning laser ophthalmoscopy images the microvasculature of choroidal melanomas and may be capable of detecting microvasculature patterns that have been shown to be prognostically significant from histopathological studies.Arch Ophthalmol. 1998;116:31-39-->

Details

Title: Subtitle: Imaging the Microvasculature of Choroidal Melanomas With Confocal Indocyanine Green Scanning Laser Ophthalmoscopy
Creators: Arthur J Mueller
Dirk-Uwe Bartsch
Robert Folberg
Mary G Mehaffey
H. Culver Boldt
Margaret Meyer
Lynn M Gardner
Michael H Goldbaum
Jacob Pe'er
William R Freeman
Resource Type: Journal article
Publication Details: Archives of ophthalmology (1960), Vol.116(1), pp.31-39
DOI: 10.1001/archopht.116.1.31
PMID: 9445206
NLM abbreviation: Arch Ophthalmol
ISSN: 0003-9950
eISSN: 1538-3601
Publisher: American Medical Association
Language: English
Date published: 01/01/1998
Academic Unit: Ophthalmology and Visual Sciences
Record Identifier: 9984083247502771

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