Journal article
Immediate neural impact and incomplete compensation after semantic hub disconnection
Nature communications, Vol.14(1), 6264
10/07/2023
DOI: 10.1038/s41467-023-42088-7
PMCID: PMC10560235
PMID: 37805497
Abstract
The human brain extracts meaning using an extensive neural system for semantic knowledge. Whether broadly distributed systems depend on or can compensate after losing a highly interconnected hub is controversial. We report intracranial recordings from two patients during a speech prediction task, obtained minutes before and after neurosurgical treatment requiring disconnection of the left anterior temporal lobe (ATL), a candidate semantic knowledge hub. Informed by modern diaschisis and predictive coding frameworks, we tested hypotheses ranging from solely neural network disruption to complete compensation by the indirectly affected language-related and speech-processing sites. Immediately after ATL disconnection, we observed neurophysiological alterations in the recorded frontal and auditory sites, providing direct evidence for the importance of the ATL as a semantic hub. We also obtained evidence for rapid, albeit incomplete, attempts at neural network compensation, with neural impact largely in the forms stipulated by the predictive coding framework, in specificity, and the modern diaschisis framework, more generally. The overall results validate these frameworks and reveal an immediate impact and capability of the human brain to adjust after losing a brain hub.
The human brain is a distributed system composed of highly interconnected hubs. Here, patients undergoing a rare operation reveal the immediate impact and compensatory brain network changes that occur when a key hub is removed.
Details
- Title: Subtitle
- Immediate neural impact and incomplete compensation after semantic hub disconnection
- Creators
- Zsuzsanna Kocsis - University of IowaRick L. Jenison - University of Wisconsin–MadisonPeter N. Taylor - Newcastle UniversityRyan M. Calmus - Newcastle UniversityBob McMurray - University of IowaAriane E. Rhone - University of IowaMcCall E. Sarrett - Gonzaga UniversityCarolina Deifelt Streese - Iowa City, IA USAYukiko Kikuchi - Newcastle UniversityPhillip E. Gander - University of IowaJoel I. Berger - University of IowaChristopher K. Kovach - University of IowaInyong Choi - University of IowaJeremy D. Greenlee - University of IowaHiroto Kawasaki - University of IowaThomas E. Cope - University of CambridgeTimothy D. Griffiths - Newcastle UniversityMatthew A. Howard - University of IowaChristopher I. Petkov - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Nature communications, Vol.14(1), 6264
- DOI
- 10.1038/s41467-023-42088-7
- PMID
- 37805497
- PMCID
- PMC10560235
- NLM abbreviation
- Nat Commun
- ISSN
- 2041-1723
- eISSN
- 2041-1723
- Publisher
- Nature Publishing Group UK
- Grant note
- WT092606AIA / ; R01–DC04290 / ; COG MECHIDENT / ;
- Language
- English
- Date published
- 10/07/2023
- Academic Unit
- Neurology; Radiology; Communication Sciences and Disorders; Linguistics; Stead Family Department of Pediatrics; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neurosurgery; Otolaryngology; Health, Sport, and Human Physiology
- Record Identifier
- 9984474260102771
Metrics
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