Journal article
Immune Checkpoint Inhibitor Use Near the End of Life: A Single-Center Retrospective Study
Journal of palliative medicine, Vol.23(7), pp.977-979
07/01/2020
DOI: 10.1089/jpm.2019.0383
PMID: 31702481
Abstract
Background: Immune checkpoint inhibitors (ICIs) have revolutionized treatment for many patients with advanced cancer. Little is known about ICI use near the end of life. Objective: To describe ICI use near the end of life. Design: Retrospective study of patients who received ICIs and died. Setting/Subjects: Patients treated with ICIs who died between August 2014 and December 2018 (N = 441) at the University of Iowa. Measurements: Comparisons were made between patients who received ICIs <= 30 days versus patients who received ICIs >30 days before death. The same analysis was done using a cutoff of 90 days. Results: Two hundred ninety-four (67%) patients received ICIs in the last 90 days of life and 117 (27%) patients received ICIs in the last 30 days of life. Patients who received ICIs in the last 30 days of life received fewer mean doses and more often <= 3 total doses. They also had higher mean Eastern Cooperative Oncology Group (ECOG) scores, more patients with ECOG >= 3, higher rates of dying in the hospital, and lower hospice enrollment. Patients treated with ICIs in the last 90 days of life received fewer doses, more often <= 3 total doses, had a higher mean ECOG score, more patients with ECOG >= 3, and lower hospice enrollment. $7.1 million USD was spent on ICI medications in the last 90 days of life. Conclusion: ICI use near the end of life is associated with poor performance status, lower hospice enrollment, dying in the hospital, financial toxicity, and minimal clinical benefit.
Details
- Title: Subtitle
- Immune Checkpoint Inhibitor Use Near the End of Life: A Single-Center Retrospective Study
- Creators
- Chad Glisch - Medical College of WisconsinSeyedehtanaz Saeidzadeh - University of IowaTravis Snyders - University of IowaStephanie Gilbertson-White - University of IowaYuya Hagiwara - University of Iowa Hospitals and ClinicsLaurel Lyckholm - University of Iowa Hospitals and Clinics
- Resource Type
- Journal article
- Publication Details
- Journal of palliative medicine, Vol.23(7), pp.977-979
- Publisher
- Mary Ann Liebert, Inc
- DOI
- 10.1089/jpm.2019.0383
- PMID
- 31702481
- ISSN
- 1096-6218
- eISSN
- 1557-7740
- Number of pages
- 3
- Language
- English
- Date published
- 07/01/2020
- Academic Unit
- Nursing; General Internal Medicine; Internal Medicine
- Record Identifier
- 9984359765202771
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