Journal article
Immune Modulation Therapy and Imaging: Workshop Report
The Journal of nuclear medicine (1978), Vol.59(3), pp.410-417
03/2018
DOI: 10.2967/jnumed.117.195610
PMCID: PMC5868498
PMID: 28818991
Abstract
A workshop at the National Cancer Institute on May 2, 2016, considered the current state of imaging in assessment of immunotherapy. Immunotherapy has shown some remarkable and prolonged responses in the treatment of tumors. However, responses are variable and frequently delayed, complicating the evaluation of new immunotherapy agents and customizing treatment for individual patients. Early anatomic imaging may show that a tumor has increased in size, but this could represent pseudoprogression. On the basis of imaging, clinicians must decide if they should stop, pause, or continue treatment. Other imaging technologies and approaches are being developed to improve the measurement of response in patients receiving immunotherapy. Imaging methods that are being evaluated include radiomic methods using CT, MRI, and
F-FDG PET, as well as new radiolabeled small molecules, antibodies, and antibody fragments to image the tumor microenvironment, immune status, and changes over the course of therapy. Current studies of immunotherapy can take advantage of these available imaging options to explore and validate their use. Collection of CT, PET, and MR images along with outcomes from trials is critical to develop improved methods of assessment.
Details
- Title: Subtitle
- Immune Modulation Therapy and Imaging: Workshop Report
- Creators
- Anthony F Shields - National Cancer Institute, Bethesda, MarylandPaula M Jacobs - National Cancer Institute, Bethesda, MarylandMario Sznol - Yale University, New Haven, ConnecticutMichael M Graham - University of Iowa, Iowa City, IowaRon N Germain - National Cancer Institute, Bethesda, MarylandLawrence G Lum - University of Virginia, Charlottesville, VirginiaElizabeth M Jaffee - Johns Hopkins University, Baltimore, MarylandElisabeth G E de Vries - University of Groningen Medical Center, Groningen, The NetherlandsSridhar Nimmagadda - Johns Hopkins University, Baltimore, MarylandAnnick D Van den Abbeele - Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MassachusettsDavid K Leung - Bristol-Myers Squibb, Princeton, New Jersey; andAnna M Wu - Crump Institute for Molecular Imaging, David Geffen School of Medicine at UCLA, Los Angeles, CaliforniaElad Sharon - National Cancer Institute, Bethesda, MarylandLalitha K Shankar - National Cancer Institute, Bethesda, Maryland
- Resource Type
- Journal article
- Publication Details
- The Journal of nuclear medicine (1978), Vol.59(3), pp.410-417
- Publisher
- United States
- DOI
- 10.2967/jnumed.117.195610
- PMID
- 28818991
- PMCID
- PMC5868498
- ISSN
- 0161-5505
- eISSN
- 1535-5667
- Grant note
- UL1 TR001863 / NCATS NIH HHS P30 CA086862 / NCI NIH HHS
- Language
- English
- Date published
- 03/2018
- Academic Unit
- Radiology; Radiation Oncology
- Record Identifier
- 9984047706302771
Metrics
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