Immune Profile and MRI-Detected Cardiac Fibrosis and Edema in Hypertensive and Non-Hypertensive Patients with COVID-19

Renata Moll-Bernardes; Gabriel C. Camargo; Andréa Silvestre-Sousa; Julia Machado Barroso; Juliana R. Ferreira; Mariana B. Tortelly; Adriana L. Pimentel; Ana Cristina B.S. Figueiredo; Eduardo B. Schaustz; José Carlos P. Secco; Sergio C. Fortier; Narendra Vera; Luciana Conde; Mauro Jorge Cabral-Castro; Denilson C. Albuquerque; Paulo H. Rosado-de-Castro; Martha V.T. Pinheiro; Olga F. Souza; Ronir R. Luiz; Emiliano Medei

doi:10.3390/jcm13237317

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Immune Profile and MRI-Detected Cardiac Fibrosis and Edema in Hypertensive and Non-Hypertensive Patients with COVID-19

Renata Moll-Bernardes, Gabriel C. Camargo, Andréa Silvestre-Sousa, Julia Machado Barroso, Juliana R. Ferreira, Mariana B. Tortelly, Adriana L. Pimentel, Ana Cristina B.S. Figueiredo, Eduardo B. Schaustz, José Carlos P. Secco, …

Journal of clinical medicine, Vol.13(23), 7317

12/02/2024

DOI: 10.3390/jcm13237317

PMID: 39685774

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Abstract

Cardiac involvement in 2019 coronavirus disease (COVID-19) survivors has been reported frequently. An exacerbated immune response may be the main mechanism of myocardial injury and late cardiac sequelae in this population. Background/Objectives: We investigated the immune profile in hypertensive and non-hypertensive patients with COVID-19 who developed late cardiac fibrosis and edema, as detected by magnetic resonance imaging (MRI). Methods: We evaluated associations of cytokine and immune-cell subset levels during hospitalization for COVID-19 with the presence of myocardial interstitial fibrosis [represented by the extracellular volume (ECV)] or edema (represented by the T2), detected by cardiac MRI examination after discharge, in hypertensive and non-hypertensive patients. Results: Patients with hypertension had reduced B-cell percentages, increased natural killer cell percentages, and higher interleukin (IL)-4, IL-5, IL-13, IL-17A, and tumor necrosis factor-β levels compared to patients without hypertension. Larger percentages of human leukocyte antigen DR isotope+ blood cells, reflecting CD8+ T-cell activation, correlated with increased T2 and ECV in hypertensive patients. The HLA-DR mean fluorescence intensity was associated with ECV in non-hypertensive patients. Conclusions: Our findings reveal cytokine and immune-cell dysregulation in both hypertensive and non-hypertensive patients with COVID-19, along with moderate correlations between CD8+ T-cell activation and increased cardiac MRI markers of myocardial interstitial fibrosis and edema. These results contribute to a deeper understanding of immune dysfunction mechanisms involved in myocardial remodeling.

Hypertension

Immune System

CD8

COVID-19

extracellular volume

myocardial fibrosis

Details

Title: Subtitle: Immune Profile and MRI-Detected Cardiac Fibrosis and Edema in Hypertensive and Non-Hypertensive Patients with COVID-19
Creators: Renata Moll-Bernardes - D’Or Institute for Research and Education
Gabriel C. Camargo - D’Or Institute for Research and Education
Andréa Silvestre-Sousa - Fundação Oswaldo Cruz
Julia Machado Barroso - D’Or Institute for Research and Education
Juliana R. Ferreira - D’Or Institute for Research and Education
Mariana B. Tortelly - D’Or Institute for Research and Education
Adriana L. Pimentel - D’Or Institute for Research and Education
Ana Cristina B.S. Figueiredo - D’Or Institute for Research and Education
Eduardo B. Schaustz - D’Or Institute for Research and Education
José Carlos P. Secco - D’Or Institute for Research and Education
Sergio C. Fortier - D’Or Institute for Research and Education
Narendra Vera - Universidade Federal do Rio de Janeiro
Luciana Conde - Universidade Federal do Rio de Janeiro
Mauro Jorge Cabral-Castro - Universidade Federal Fluminense
Denilson C. Albuquerque - Universidade do Estado do Rio de Janeiro
Paulo H. Rosado-de-Castro - D’Or Institute for Research and Education
Martha V.T. Pinheiro - D’Or Institute for Research and Education
Olga F. Souza - D’Or Institute for Research and Education
Ronir R. Luiz - D’Or Institute for Research and Education
Emiliano Medei - D’Or Institute for Research and Education
Resource Type: Journal article
Publication Details: Journal of clinical medicine, Vol.13(23), 7317
DOI: 10.3390/jcm13237317
PMID: 39685774
NLM abbreviation: J Clin Med
ISSN: 2077-0383
eISSN: 2077-0383
Grant note: Financiadora de Estudos e Projetos (http://data.elsevier.com/vocabulary/SciValFunders/501100004809) Instituto Serrapilheira (501100013275) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (http://data.elsevier.com/vocabulary/SciValFunders/501100002322) SEI-260003/002718/2020; E-26/010.000149/2020; E-26/210.253/2020; SEI-260003/011968/2021; SEI-260003/002709/2020; E-26/210.155/2020; E-26/210.191/2020 / Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (http://data.elsevier.com/vocabulary/SciValFunders/501100004586) D’Or Institute for Research and Education Instituto Serrapilheira (http://data.elsevier.com/vocabulary/SciValFunders/501100013275) Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (http://data.elsevier.com/vocabulary/SciValFunders/501100004586) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (501100002322) Financiadora de Estudos e Projetos (501100004809)
Language: English
Date published: 12/02/2024
Academic Unit: Radiology
Record Identifier: 9985143126102771

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